Document Detail

Hypertrophic cardiomyopathy: functional aspects by tagged magnetic resonance imaging.
MedLine Citation:
PMID:  8540406     Owner:  NLM     Status:  MEDLINE    
Studies addressing the issue of regional function in hypertrophic cardiomyopathy patients (HCM) are reviewed. The relationship between regional wall thickness and function in these patients was studied by three dimensional (3D) tagged magnetic resonance imaging (MRI) utilizing the volume-element approach. Regional function was indexed by myocardial thickening and circumferential shortening and related to the local thickness and wall stress index. An inverse relationship was found between wall thickening and thickness as well as between circumferential shortening and wall thickness. Lower stresses were obtained for thicker myocardial segments. Function of the normal-thickness regions was enhanced in the HCM patients relative to the normal subjects. Thicker segments in patients with HCM are thus characterized by reduced systolic function, which occurs at segments with relatively low stress levels. This pattern is consistent with the hypothesis that the thick myocardial segments have reduced contractile activity, probably due to recently identified mutations in the gene responsible for production of beta heavy chain myosin as well as other contractile proteins.
R Beyar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  382     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  1995  
Date Detail:
Created Date:  1996-02-02     Completed Date:  1996-02-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  293-301     Citation Subset:  IM    
Julius Silver Institute of Biomedical Engineering, Technion-IIT, Haifa, Israel.
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MeSH Terms
Cardiomyopathy, Hypertrophic / diagnosis*,  physiopathology
Magnetic Resonance Imaging

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