Document Detail

Hypertrophic cardiomyopathy evolving into a hypokinetic and dilated left ventricle: coronary embolization as a probable pathogenetic mechanism.
MedLine Citation:
PMID:  2364585     Owner:  NLM     Status:  MEDLINE    
A long-term follow-up (9 years) in a patient with hypertrophic cardiomyopathy revealed an evolution to a hypokinetic and dilated left ventricle. The patient underwent heart transplantation, and therefore the native heart was available for morphologic studies. Gross and microscopic stigmata of hypertrophic cardiomyopathy were present, as well as evidence of left ventricular dilatation. Multiple myocardial scars in both ventricles indicated past ischemic episodes, most probably due to coronary embolization from left ventricular mural thrombi. Other possible pathogenetic mechanisms for the progression of hypertrophic cardiomyopathy to a dilated one are discussed.
M B Gravanis; P H Robinson; G L Hertzler
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical cardiology     Volume:  13     ISSN:  0160-9289     ISO Abbreviation:  Clin Cardiol     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-08-13     Completed Date:  1990-08-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  500-5     Citation Subset:  IM    
Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322.
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MeSH Terms
Cardiomyopathy, Dilated / etiology,  pathology*,  physiopathology
Cardiomyopathy, Hypertrophic / pathology*
Coronary Disease / complications*,  pathology
Embolism / complications*,  pathology
Follow-Up Studies
Heart Diseases / complications,  pathology
Heart Ventricles / pathology,  physiopathology
Middle Aged
Myocardial Contraction
Thrombosis / complications,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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