Document Detail

Hypertrophic cardiomyopathy: the early years.
MedLine Citation:
PMID:  20559993     Owner:  NLM     Status:  MEDLINE    
Hypertrophic obstructive cardiomyopathy (HOCM) has four major features: (1) severe left ventricular hypertrophy, often most prominent in the basal interventricular septum; (2) frequent familial occurrence with autosomal dominant transmission; (3) occurrence of sudden cardiac death that is usually considered to be due to ventricular fibrillation; and (4) presence of hemodynamic evidence of labile intraventricular obstruction. The key papers describing the recognition of each of these features, as well as of various combinations of them, are reviewed in this paper. Particular attention is focused on the very frequent finding of marked lability of intraventricular obstruction. The recognition of this fourth and last major feature in 1959 makes 2009 the golden anniversary year marking completion of the description of the major features of HOCM.
Eugene Braunwald
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Publication Detail:
Type:  Historical Article; Journal Article; Review     Date:  2009-10-07
Journal Detail:
Title:  Journal of cardiovascular translational research     Volume:  2     ISSN:  1937-5395     ISO Abbreviation:  J Cardiovasc Transl Res     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-06-18     Completed Date:  2010-11-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101468585     Medline TA:  J Cardiovasc Transl Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  341-8     Citation Subset:  IM    
Harvard Medical School, Boston, MA, USA.
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MeSH Terms
Cardiomyopathy, Hypertrophic / complications,  history*,  physiopathology,  therapy
Cardiomyopathy, Hypertrophic, Familial / complications,  history*,  physiopathology,  therapy
Death, Sudden, Cardiac / etiology
Genetic Predisposition to Disease
History, 20th Century
History, 21st Century
Hypertrophy, Left Ventricular / etiology,  history
Treatment Outcome
Ventricular Outflow Obstruction / etiology,  history

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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