| Hypertrophic cardiomyopathy: the early years. | |
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MedLine Citation:
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PMID: 20559993 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypertrophic obstructive cardiomyopathy (HOCM) has four major features: (1) severe left ventricular hypertrophy, often most prominent in the basal interventricular septum; (2) frequent familial occurrence with autosomal dominant transmission; (3) occurrence of sudden cardiac death that is usually considered to be due to ventricular fibrillation; and (4) presence of hemodynamic evidence of labile intraventricular obstruction. The key papers describing the recognition of each of these features, as well as of various combinations of them, are reviewed in this paper. Particular attention is focused on the very frequent finding of marked lability of intraventricular obstruction. The recognition of this fourth and last major feature in 1959 makes 2009 the golden anniversary year marking completion of the description of the major features of HOCM. |
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Authors:
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Eugene Braunwald |
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Publication Detail:
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Type: Historical Article; Journal Article; Review Date: 2009-10-07 |
Journal Detail:
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Title: Journal of cardiovascular translational research Volume: 2 ISSN: 1937-5395 ISO Abbreviation: J Cardiovasc Transl Res Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2010-06-18 Completed Date: 2010-11-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101468585 Medline TA: J Cardiovasc Transl Res Country: United States |
Other Details:
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Languages: eng Pagination: 341-8 Citation Subset: IM |
Affiliation:
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Harvard Medical School, Boston, MA, USA. ebraunwald@partners.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cardiomyopathy, Hypertrophic
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complications,
history*,
physiopathology,
therapy Cardiomyopathy, Hypertrophic, Familial / complications, history*, physiopathology, therapy Death, Sudden, Cardiac / etiology Genetic Predisposition to Disease Hemodynamics History, 20th Century History, 21st Century Humans Hypertrophy, Left Ventricular / etiology, history Treatment Outcome Ventricular Outflow Obstruction / etiology, history |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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