| Hypertriglyceridemia and hypercholesterolemia: effects of drug treatment on fatty acid composition of plasma lipids and membranes. | |
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MedLine Citation:
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PMID: 18502109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of atorvastatin, simvastatin and gemfibrozil on fatty acid composition of plasma phospholipids (PL), cholesterol esters (CE), triglycerides (TG) and red cell membrane ghosts (G) has been determined in appropriate sample populations of individuals with hypertriglyceridemia (HTG) or hypercholesterolemia (HCHL). Treatments were appropriate for the condition, gemfibrozil for HTG and a statin for HCHL. Modifications depend on the drug and lipid fraction examined. Both classes of drugs modify fatty acid composition but gemfibrozil modifications are more numerous and dramatic than are the modifications by statins. Gemfibrozil produces major modifications in fatty acid composition, which are both fatty acid and lipid class specific but generally decreases SFA and increases PUFA (mainly n6) and increases the proportion of fatty acids with chain length of 18C or more. Statins tend to increase chain length but have less effect on saturation. Notably, all three drugs increased arachidonic acid (AA) in PL and CE. Statins decreased gamma-linoleic acid (GLA) in PL and CE but gemfibrozil only increased GLA in TG. |
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Authors:
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John O Nyalala; Jiang Wang; An Dang; Fred H Faas; W Grady Smith |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2008-05-23 |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and essential fatty acids Volume: 78 ISSN: 0952-3278 ISO Abbreviation: Prostaglandins Leukot. Essent. Fatty Acids Publication Date: 2008 Apr-May |
Date Detail:
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Created Date: 2008-06-16 Completed Date: 2008-10-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8802730 Medline TA: Prostaglandins Leukot Essent Fatty Acids Country: Scotland |
Other Details:
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Languages: eng Pagination: 271-80 Citation Subset: IM |
Affiliation:
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Departments of Biochemistry & Molecular Biology and Medicine, University of Arkansas for Medical Sciences, McClellan VA Hospital, 4301 W Markham, Little Rock, AR 72205, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Membrane
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drug effects*,
metabolism Fatty Acids / analysis*, blood, chemistry Gemfibrozil / therapeutic use Heptanoic Acids / therapeutic use Humans Hypercholesterolemia / blood*, drug therapy* Hypertriglyceridemia / blood*, drug therapy* Lipids / analysis, blood*, chemistry Pyrroles / therapeutic use Simvastatin / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Heptanoic Acids; 0/Lipids; 0/Pyrroles; 110862-48-1/atorvastatin; 25812-30-0/Gemfibrozil; 79902-63-9/Simvastatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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