Document Detail

Hypertransaminasemia with subcutaneous heparin therapy.
MedLine Citation:
PMID:  7327913     Owner:  NLM     Status:  MEDLINE    
An elevation of serum aspartate aminotransferase (GOT) and alanine aminotransferase (GPT) may be produced in patients treated with i.v. full-dose HEPARIN. We studied the influence of low-dose s.c. HEPARIN (5,000 IU X 2) in 34 patients with acute myocardial infarction (AMI) and in 7 with cerebrovascular accidents or calf thrombophlebitis. Twelve patients (all males) with AMI showed a secondary elevation of GOT and GPT at about the sixth or seventh day after the commencement of therapy that persisted throughout the period of treatment. Four patients (two males and two females) with cerebrovascular accidents or thrombophlebitis showed similar increases of GOT and GPT.
S Shilo; A S Abraham; R Breuer; M Sonnenblick
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Israel journal of medical sciences     Volume:  17     ISSN:  0021-2180     ISO Abbreviation:  Isr. J. Med. Sci.     Publication Date:  1981 Dec 
Date Detail:
Created Date:  1982-04-20     Completed Date:  1982-04-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0013105     Medline TA:  Isr J Med Sci     Country:  ISRAEL    
Other Details:
Languages:  eng     Pagination:  1133-5     Citation Subset:  IM    
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MeSH Terms
Alanine Transaminase / blood*
Aspartate Aminotransferases / blood*
Heparin / pharmacology*,  therapeutic use
Myocardial Infarction / drug therapy*,  enzymology
Reg. No./Substance:
9005-49-6/Heparin; EC Aminotransferases; EC Transaminase

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