Document Detail

Hypertonic sodium chloride solutions: effect on hemodynamics and survival after hemorrhage in swine.
MedLine Citation:
PMID:  3806709     Owner:  NLM     Status:  MEDLINE    
We evaluated the hemodynamic response of 12% shed blood replacement with 7.5% sodium chloride after a nonlethal hemorrhage in chronically instrumented swine. Compared to no treatment or Ringer's lactate infusion, the hypertonic salt solution was followed by increased cardiac output. We then evaluated the effect of hypertonic sodium chloride on survival after an otherwise lethal hemorrhage in chronically instrumented and unanesthetized swine. Survival was significantly greater after replacement of 25% of the shed blood with 7.5%, but not with 0.9%, 5.0%, or 10.0% sodium chloride solution. The mechanism appears to be by increased tissue perfusion as indicated by lower lactate values. Resuscitation with low-volume hypertonic sodium chloride may be life saving and life supporting during the initial treatment of trauma patients when conventional therapy is not available.
L W Traverso; R F Bellamy; S J Hollenbach; L D Witcher
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of trauma     Volume:  27     ISSN:  0022-5282     ISO Abbreviation:  J Trauma     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-02-27     Completed Date:  1987-02-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376373     Medline TA:  J Trauma     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  32-9     Citation Subset:  AIM; IM    
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MeSH Terms
Cardiac Output
Fluid Therapy*
Hemodynamics / drug effects*
Isotonic Solutions / therapeutic use
Saline Solution, Hypertonic / therapeutic use*
Shock, Hemorrhagic / mortality,  therapy*
Sodium Chloride / therapeutic use*
Reg. No./Substance:
0/Isotonic Solutions; 0/Saline Solution, Hypertonic; 7647-14-5/Sodium Chloride; 8022-63-7/Ringer's lactate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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