| Hypertonic-hyperoncotic solutions reduce the release of cardiac troponin I and s-100 after successful cardiopulmonary resuscitation in pigs. | |
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MedLine Citation:
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PMID: 12351289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In some patients, cardiopulmonary resuscitation (CPR) can revive spontaneous circulation (ROSC). However, neurological outcome often remains poor. Hypertonic-hyperoncotic solutions (HHS) have been shown to improve microvascular conductivity after regional and global ischemia. We investigated the effect of infusion of HHS in a porcine CPR model. Cardiac arrest was induced by ventricular fibrillation. Advanced cardiac life support was begun after 4 min of nonintervention and 1 min of basic life support. Upon ROSC, the animals randomly received 125 mL of either normal saline (placebo, n = 8) or 7.2% NaCl and 10% hydroxyethyl starch 200,000/0.5 (HHS, n = 7). Myocardial and cerebral damage were assessed by serum concentrations of cardiac troponin I and astroglial protein S-100, respectively, up to 240 min after ROSC. In all animals, the levels of cardiac troponin I and S-100 increased after ROSC (P < 0.01). This increase was significantly blunted in animals that received HHS instead of placebo. The use of HHS in the setting of CPR may provide a new option in reducing cell damage in postischemic myocardial and cerebral tissues. IMPLICATIONS: Infusion of hypertonic-hyperoncotic solutions (HHS) after successful cardiopulmonary resuscitation in pigs significantly reduced the release of cardiac troponin I and cerebral protein S-100, which are sensitive and specific markers of cell damage. Treatment with HHS may provide a new option to improve the outcome of cardiopulmonary resuscitation. |
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Authors:
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Heiner Krieter; Christof Denz; Christoph Janke; Thomas Bertsch; Thomas Luiz; Klaus Ellinger; Klaus Van Ackern |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anesthesia and analgesia Volume: 95 ISSN: 0003-2999 ISO Abbreviation: Anesth. Analg. Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-09-27 Completed Date: 2002-10-28 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: United States |
Other Details:
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Languages: eng Pagination: 1031-6, table of contents Citation Subset: AIM; IM |
Affiliation:
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Institutes of Anesthesiology and Intensive Care Medicine and Clinical Chemistry, Faculty of Clinical Medicine Mannheim, University of Heidelberg, Mannheim, Germany. heiner.krieter@anaes.ma.uni-heidelberg.de |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Markers Cardiopulmonary Resuscitation* Electric Countershock Epinephrine / therapeutic use Female Heart Arrest / physiopathology, therapy Hemodynamics / physiology Hemoglobins / metabolism Hypertonic Solutions / therapeutic use* Ischemia / drug therapy Male Reperfusion Injury / therapy S100 Proteins / metabolism* Swine Troponin I / metabolism* Vasoconstrictor Agents / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Hemoglobins; 0/Hypertonic Solutions; 0/S100 Proteins; 0/Troponin I; 0/Vasoconstrictor Agents; 51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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