Document Detail

Hypertonic and hyperoncotic resuscitation from severe hemorrhagic shock in dogs: a comparative study.
MedLine Citation:
PMID:  2465867     Owner:  NLM     Status:  MEDLINE    
Single bolus injections of hypertonic (7.5%) NaCl (H), hyperoncotic (6%) dextran-70 (D), or of their combination (HD) were given to severely bled (54.2 +/- 1.3 ml/kg) anesthetized dogs. Two shock procedures (30 or 60 min at 35 mm Hg) were tested. Survival was highest (11/12) after HD, lower (9/12) after H, and lowest (7/12) after D; it was higher (15/18 vs. 12/18) after the shorter vs. longer shock procedure. Cardiac index (CI) was restored to 83%-104% of prehemorrhage levels immediately after HD or H; 3 h later it was down to 67%-71% of control; after D, CI was stable at 41% to 50% of control; no differences in the relative performances of the agents tested in the 30 or 60-min shock durations. Arterial pressure recovered to near control levels in all groups; consequently, systemic vascular resistance was reduced after H and HD, but increased after D. Plasma volume recovered to 95% of control after H, 105% of control after HD, but only to 80% after D; however, the response to H was transient. Metabolic acidosis was partially reverted by all solutions. Plasma Na+ was transiently raised by H and HD. Overall differences detected between H vs. HD tend to favor HD as a resuscitative solution.
I T Velasco; M Rocha e Silva; M A Oliveira; M A Oliveira; R I Silva
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Critical care medicine     Volume:  17     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-04-07     Completed Date:  1989-04-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  261-4     Citation Subset:  AIM; IM    
Research Division, Faculdade de Medicina, Universidade de São Paulo, Brazil.
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MeSH Terms
Blood Gas Analysis
Blood Pressure / drug effects
Blood Transfusion, Autologous
Blood Volume
Cardiac Output / drug effects
Dextrans / administration & dosage,  therapeutic use*
Drug Combinations
Saline Solution, Hypertonic / administration & dosage,  therapeutic use*
Shock, Hemorrhagic / drug therapy*
Sodium Chloride / therapeutic use*
Reg. No./Substance:
0/Drug Combinations; 0/Saline Solution, Hypertonic; 7647-14-5/Sodium Chloride; 9004-54-0/Dextrans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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