Document Detail

Hyperthyroidism in pregnancy: diagnosis and treatment.
MedLine Citation:
PMID:  10447008     Owner:  NLM     Status:  MEDLINE    
Hyperthyroidism due to autoimmune Graves' disease is the leading cause of thyrotoxicosis in pregnant women. The peak incidence of the disease is in the second through the fourth decade of life, which encompasses the reproductive years for women. Although menstrual irregularity is frequent in women with mild to moderate hyperthyroidism, convincing evidence that fertility is impaired is lacking. In general, 2 of every 1000 pregnancies have been reported to be complicated by hyperthyroidism. Hyperthyroidism associated with pregnancy may pose a challenging diagnostic and therapeutic dilemma. The current review focuses on the discussion of symptomatology and diagnosis of the disease, on therapeutic options available to women presenting with hyperthyroidism during gestation, and on the controversy surrounding maternal and fetal outcome in pregnancies complicated by thyrotoxicosis.
U S Masiukiewicz; G N Burrow
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Thyroid : official journal of the American Thyroid Association     Volume:  9     ISSN:  1050-7256     ISO Abbreviation:  Thyroid     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-09-21     Completed Date:  1999-09-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9104317     Medline TA:  Thyroid     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  647-52     Citation Subset:  IM    
Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8050, USA.
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use
Antithyroid Agents / therapeutic use
Graves Disease / complications,  diagnosis,  therapy
Hyperthyroidism / diagnosis*,  therapy*
Iodine Radioisotopes / therapeutic use
Pregnancy Complications / diagnosis*,  therapy*
Pregnancy Outcome
Propylthiouracil / therapeutic use
Thyrotoxicosis / etiology
Grant Support
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Antithyroid Agents; 0/Iodine Radioisotopes; 51-52-5/Propylthiouracil

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