Document Detail

Hyperthyroidism is associated with shortened APTT and increased fibrinogen values in a general population of unselected outpatients.
MedLine Citation:
PMID:  18787930     Owner:  NLM     Status:  MEDLINE    
Although clinical evidence supports a plausible association between thyroid disorders and venous thrombosis, reliable evidence is so far lacking on the potential biological mechanisms and neither temporary nor permanent thromboembolic risk factors were constantly identified. We performed a 2-years retrospective analysis to retrieve combined results of activated partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen, and thyroid stimulating hormone (TSH), performed on outpatients over 15 years of age and referred by general practitioners for routine blood testing. Cumulative results were retrieved for 1,329 such outpatients. Patients with hyperthyroidism had shortened APTT (28.4 vs. 29.4 s; P = 0.043) and higher fibrinogen (4.1 vs. 3.8 g/l; P = 0.028) values when compared with euthyroid patients, whereas no significant differences were observed between euthyroid patients and those with hypothyroidism. Hyperthyroid patients had also an increased prevalence of shortened APTTs (<25.5 s) and higher values of fibrinogen (>4.0 g/l) than those with normal thyroid function. This study confirms that hyperthyroidism might be associated with hypercoagulability due to shortened APTT and increased fibrinogen values. Should these findings be confirmed, consideration should be given to prevent thrombotic complications in patients with hyperthyroidism.
Giuseppe Lippi; Massimo Franchini; Giovanni Targher; Martina Montagnana; Gian Luca Salvagno; Gian Cesare Guidi; Emmanuel J Favaloro
Publication Detail:
Type:  Journal Article     Date:  2008-09-12
Journal Detail:
Title:  Journal of thrombosis and thrombolysis     Volume:  28     ISSN:  1573-742X     ISO Abbreviation:  J. Thromb. Thrombolysis     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-04     Completed Date:  2009-12-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9502018     Medline TA:  J Thromb Thrombolysis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  362-5     Citation Subset:  IM    
Sezione di Chimica Clinica, Dipartimento di Scienze Morfologico-Biomediche, Universit?? degli Studi di Verona, Ospedale Policlinico GB Rossi, Piazzale Scuro, Verona, Italy.
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MeSH Terms
Aged, 80 and over
Fibrinogen / analysis*
Hyperthyroidism / blood*,  complications
Middle Aged
Partial Thromboplastin Time*
Retrospective Studies
Thrombophilia / etiology
Reg. No./Substance:

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