| Hyperthermic intraperitoneal chemoperfusion (HIPEC) decrease wound strength of colonic anastomosis in a rat model. | |
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MedLine Citation:
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PMID: 17245567 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND AIMS: There is controversy about the effect of the influence of hyperthermia and chemotherapeutic agents on the healing of intestinal anastomosis. The effects of hyperthermic intraperitoneal chemoperfusion (HIPEC) of wound healing after colonic anastomosis were investigated in a rat model. MATERIALS AND METHODS: Thirty-six Wag/Rija rats were randomized into three groups of 12 animals each: group I: control (only colonic anastomosis was performed) (n = 12); group II: HIPEC (mitomycin C in a concentration of 20 mg/m(2) (n = 12) colonic anastomosis was performed before HIPEC; group III: HIPEC (mitomycin C in a concentration of 20 mg/m(2) (n = 12) colonic anastomosis was performed after HIPEC. Bursting pressure and bursting sites were recorded 4 and 10 days after intervention. Collagen deposits, inflammation and foreign body reactions were evaluated. RESULTS: Lower bursting pressure and lost of collagen were found in both HIPEC groups and compared with the control group. There was almost no difference between both HIPEC groups. They were noted overwhelmingly at the anastomosis in the HIPEC group. The degree of collagen accumulation was well-correlated with bursting pressure. CONCLUSION: These results have shown that hyperthermic intraperitoneal chemoperfusion (HIPEC) impairs wound healing in colonic anastomosis in rats. |
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Authors:
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J O W Pelz; J Doerfer; M Decker; A Dimmler; W Hohenberger; T Meyer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-01-24 |
Journal Detail:
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Title: International journal of colorectal disease Volume: 22 ISSN: 0179-1958 ISO Abbreviation: Int J Colorectal Dis Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-06-14 Completed Date: 2008-01-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8607899 Medline TA: Int J Colorectal Dis Country: Germany |
Other Details:
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Languages: eng Pagination: 941-7 Citation Subset: IM |
Affiliation:
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Department of Surgery, University of Erlangen-Nuremberg, Krankenhausstrasse 12, 91054, Erlangen, Germany.. joerg.pelz@chir.imed.uni-erlangen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anastomosis, Surgical Animals Antibiotics, Antineoplastic / administration & dosage* Chemotherapy, Cancer, Regional Perfusion* Collagen / metabolism Colon / drug effects*, metabolism, physiopathology, surgery Digestive System Surgical Procedures* / adverse effects Down-Regulation Foreign-Body Reaction / etiology, pathology Hypothermia, Induced* Inflammation / etiology, pathology Male Mitomycin / administration & dosage* Models, Animal Pressure Rats Rats, Inbred Strains Tensile Strength Time Factors Wound Healing / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Antibiotics, Antineoplastic; 50-07-7/Mitomycin; 9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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