Document Detail

Hyperthermic intraperitoneal chemoperfusion (HIPEC) decrease wound strength of colonic anastomosis in a rat model.
MedLine Citation:
PMID:  17245567     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIMS: There is controversy about the effect of the influence of hyperthermia and chemotherapeutic agents on the healing of intestinal anastomosis. The effects of hyperthermic intraperitoneal chemoperfusion (HIPEC) of wound healing after colonic anastomosis were investigated in a rat model. MATERIALS AND METHODS: Thirty-six Wag/Rija rats were randomized into three groups of 12 animals each: group I: control (only colonic anastomosis was performed) (n = 12); group II: HIPEC (mitomycin C in a concentration of 20 mg/m(2) (n = 12) colonic anastomosis was performed before HIPEC; group III: HIPEC (mitomycin C in a concentration of 20 mg/m(2) (n = 12) colonic anastomosis was performed after HIPEC. Bursting pressure and bursting sites were recorded 4 and 10 days after intervention. Collagen deposits, inflammation and foreign body reactions were evaluated. RESULTS: Lower bursting pressure and lost of collagen were found in both HIPEC groups and compared with the control group. There was almost no difference between both HIPEC groups. They were noted overwhelmingly at the anastomosis in the HIPEC group. The degree of collagen accumulation was well-correlated with bursting pressure. CONCLUSION: These results have shown that hyperthermic intraperitoneal chemoperfusion (HIPEC) impairs wound healing in colonic anastomosis in rats.
J O W Pelz; J Doerfer; M Decker; A Dimmler; W Hohenberger; T Meyer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-01-24
Journal Detail:
Title:  International journal of colorectal disease     Volume:  22     ISSN:  0179-1958     ISO Abbreviation:  Int J Colorectal Dis     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-06-14     Completed Date:  2008-01-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607899     Medline TA:  Int J Colorectal Dis     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  941-7     Citation Subset:  IM    
Department of Surgery, University of Erlangen-Nuremberg, Krankenhausstrasse 12, 91054, Erlangen, Germany..
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MeSH Terms
Anastomosis, Surgical
Antibiotics, Antineoplastic / administration & dosage*
Chemotherapy, Cancer, Regional Perfusion*
Collagen / metabolism
Colon / drug effects*,  metabolism,  physiopathology,  surgery
Digestive System Surgical Procedures* / adverse effects
Foreign-Body Reaction / etiology,  pathology
Hypothermia, Induced*
Inflammation / etiology,  pathology
Mitomycin / administration & dosage*
Models, Animal
Rats, Inbred Strains
Tensile Strength
Time Factors
Wound Healing / drug effects*
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 50-07-7/Mitomycin; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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