| Hyperthermia-induced drug targeting. | |
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MedLine Citation:
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PMID: 23289519 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Introduction: Specific delivery of a drug to a target site is a major goal of drug delivery research. Using temperature-sensitive liposomes (TSLs) is one way to achieve this; the liposome acts as a protective carrier, allowing increased drug to flow through the bloodstream by minimizing clearance and non-specific uptake. On reaching microvessels within a heated tumor, the drug is released and quickly penetrates. A major advance in the field is ThermoDox® (Celsion), demonstrating significant improvements to the drug release rates and drug uptake in heated tumors (∼ 41°C). Most recently, magnetic resonance-guided focused ultrasound (MRgFUS) has been combined with TSL drug delivery to provide localized chemotherapy with simultaneous quantification of drug release within the tumor. Areas covered: In this article the field of hyperthermia-induced drug delivery is discussed, with an emphasis on the development of TSLs and their combination with hyperthermia (both mild and ablative) in cancer therapy. State-of-the-art image-guided heating technologies used with this combination strategy will also be presented, with examples of real-time monitoring of drug delivery and prediction of efficacy. Expert opinion: The specific delivery of drugs by combining hyperthermia with TSLs is showing great promise in the clinic and its potential will be even greater as the use of image-guided focused ultrasound becomes more widespread - a technique capable of penetrating deep within the body to heat a specific area with improved control. In conjunction with this, it is anticipated that multifunctional TSLs will be a major topic of study in this field. |
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Authors:
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Jonathan P May; Shyh-Dar Li |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-7 |
Journal Detail:
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Title: Expert opinion on drug delivery Volume: - ISSN: 1744-7593 ISO Abbreviation: Expert Opin Drug Deliv Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101228421 Medline TA: Expert Opin Drug Deliv Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Ontario Institute for Cancer Research, Drug Delivery and Formulation Group, Medicinal Chemistry Platform , Toronto, ON, M5G 0A3 , Canada +1 647 260 7994 ; +1 416 673 6664 ; sli@oicr.on.ca. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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