Document Detail

Hyperthermia-induced drug targeting.
MedLine Citation:
PMID:  23289519     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Specific delivery of a drug to a target site is a major goal of drug delivery research. Using temperature-sensitive liposomes (TSLs) is one way to achieve this; the liposome acts as a protective carrier, allowing increased drug to flow through the bloodstream by minimizing clearance and non-specific uptake. On reaching microvessels within a heated tumor, the drug is released and quickly penetrates. A major advance in the field is ThermoDox® (Celsion), demonstrating significant improvements to the drug release rates and drug uptake in heated tumors (∼ 41°C). Most recently, magnetic resonance-guided focused ultrasound (MRgFUS) has been combined with TSL drug delivery to provide localized chemotherapy with simultaneous quantification of drug release within the tumor.
AREAS COVERED: In this article the field of hyperthermia-induced drug delivery is discussed, with an emphasis on the development of TSLs and their combination with hyperthermia (both mild and ablative) in cancer therapy. State-of-the-art image-guided heating technologies used with this combination strategy will also be presented, with examples of real-time monitoring of drug delivery and prediction of efficacy.
EXPERT OPINION: The specific delivery of drugs by combining hyperthermia with TSLs is showing great promise in the clinic and its potential will be even greater as the use of image-guided focused ultrasound becomes more widespread - a technique capable of penetrating deep within the body to heat a specific area with improved control. In conjunction with this, it is anticipated that multifunctional TSLs will be a major topic of study in this field.
Jonathan P May; Shyh-Dar Li
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-07
Journal Detail:
Title:  Expert opinion on drug delivery     Volume:  10     ISSN:  1744-7593     ISO Abbreviation:  Expert Opin Drug Deliv     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-15     Completed Date:  2013-05-17     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  101228421     Medline TA:  Expert Opin Drug Deliv     Country:  England    
Other Details:
Languages:  eng     Pagination:  511-27     Citation Subset:  IM    
Ontario Institute for Cancer Research, Drug Delivery and Formulation Group, Medicinal Chemistry Platform, Toronto, ON, M5G 0A3, Canada.
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MeSH Terms
Antibiotics, Antineoplastic / administration & dosage
Drug Delivery Systems / methods*
Hyperthermia, Induced / methods*
Liposomes / chemistry*
Magnetic Resonance Spectroscopy
Neoplasms / drug therapy*
Technology, Pharmaceutical
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 0/Liposomes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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