Document Detail


Hyperthermia-induced drug targeting.
MedLine Citation:
PMID:  23289519     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Specific delivery of a drug to a target site is a major goal of drug delivery research. Using temperature-sensitive liposomes (TSLs) is one way to achieve this; the liposome acts as a protective carrier, allowing increased drug to flow through the bloodstream by minimizing clearance and non-specific uptake. On reaching microvessels within a heated tumor, the drug is released and quickly penetrates. A major advance in the field is ThermoDox® (Celsion), demonstrating significant improvements to the drug release rates and drug uptake in heated tumors (∼ 41°C). Most recently, magnetic resonance-guided focused ultrasound (MRgFUS) has been combined with TSL drug delivery to provide localized chemotherapy with simultaneous quantification of drug release within the tumor.
AREAS COVERED: In this article the field of hyperthermia-induced drug delivery is discussed, with an emphasis on the development of TSLs and their combination with hyperthermia (both mild and ablative) in cancer therapy. State-of-the-art image-guided heating technologies used with this combination strategy will also be presented, with examples of real-time monitoring of drug delivery and prediction of efficacy.
EXPERT OPINION: The specific delivery of drugs by combining hyperthermia with TSLs is showing great promise in the clinic and its potential will be even greater as the use of image-guided focused ultrasound becomes more widespread - a technique capable of penetrating deep within the body to heat a specific area with improved control. In conjunction with this, it is anticipated that multifunctional TSLs will be a major topic of study in this field.
Authors:
Jonathan P May; Shyh-Dar Li
Related Documents :
24099029 - How to avoid being surprised by hepatotoxicity at the final stages of drug development ...
9126219 - Stymied by seizures. when the clues point to the wrong path.
24184489 - Drug delivery design for intravenous route with integrated physicochemistry, pharmacoki...
25089559 - Impact of pharmaceutical cocrystals: the effects on drug pharmacokinetics.
23508189 - Target identification and mechanism of action in chemical biology and drug discovery.
23278299 - Illegal use of benzodiazepines and/or zolpidem proved by hair analysis.
20456999 - Genetic chemistry: production of non-native compounds in yeast.
22710939 - Sec61β controls sensitivity to platinum-containing chemotherapeutic agents through mod...
20078189 - Healthcare resource utilization following switch or discontinuation in multiple scleros...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-07
Journal Detail:
Title:  Expert opinion on drug delivery     Volume:  10     ISSN:  1744-7593     ISO Abbreviation:  Expert Opin Drug Deliv     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-15     Completed Date:  2013-05-17     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  101228421     Medline TA:  Expert Opin Drug Deliv     Country:  England    
Other Details:
Languages:  eng     Pagination:  511-27     Citation Subset:  IM    
Affiliation:
Ontario Institute for Cancer Research, Drug Delivery and Formulation Group, Medicinal Chemistry Platform, Toronto, ON, M5G 0A3, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Antibiotics, Antineoplastic / administration & dosage
Drug Delivery Systems / methods*
Humans
Hyperthermia, Induced / methods*
Liposomes / chemistry*
Magnetic Resonance Spectroscopy
Neoplasms / drug therapy*
Technology, Pharmaceutical
Temperature
Chemical
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 0/Liposomes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Iron homeostasis in the Metabolic Syndrome.
Next Document:  Enhancement in electron transport and light emission efficiency of a Si nanocrystal light-emitting d...