| Hyperthermia-induced cell death by apoptosis in myeloma cells. | |
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MedLine Citation:
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PMID: 11325215 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have analyzed by morphological (TEM) and histochemical (TUNEL reaction) criteria the type of cell death occurring in one case of human multiple myeloma after hyperthermia. Samples of cells examined immediately at the end of two treatments with a 15-day interval showed a significant degeneration, mostly demonstrating features of apoptosis (cell shrinkage, DNA fragmentation, karyorrhexis). The possible causes of the lag period between heating and apoptosis onset-expression are discussed. |
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Authors:
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S Barni; P Pontiggia; V Bertone; R Vaccarone; M G Silvotti; E Pontiggia; G Mathé |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie Volume: 55 ISSN: 0753-3322 ISO Abbreviation: Biomed. Pharmacother. Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-04-27 Completed Date: 2001-08-30 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8213295 Medline TA: Biomed Pharmacother Country: France |
Other Details:
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Languages: eng Pagination: 170-3 Citation Subset: IM |
Affiliation:
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Department of Animal Biology and CNR Center for Histochemistry, University of Pavia, Italy. barni@unipv.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Apoptosis / physiology* DNA Fragmentation Humans Hyperthermia, Induced* In Situ Nick-End Labeling Male Microscopy, Electron Multiple Myeloma / pathology, therapy*, ultrastructure |
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