Document Detail

Hyperthermia-induced cell death by apoptosis in myeloma cells.
MedLine Citation:
PMID:  11325215     Owner:  NLM     Status:  MEDLINE    
We have analyzed by morphological (TEM) and histochemical (TUNEL reaction) criteria the type of cell death occurring in one case of human multiple myeloma after hyperthermia. Samples of cells examined immediately at the end of two treatments with a 15-day interval showed a significant degeneration, mostly demonstrating features of apoptosis (cell shrinkage, DNA fragmentation, karyorrhexis). The possible causes of the lag period between heating and apoptosis onset-expression are discussed.
S Barni; P Pontiggia; V Bertone; R Vaccarone; M G Silvotti; E Pontiggia; G Mathé
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie     Volume:  55     ISSN:  0753-3322     ISO Abbreviation:  Biomed. Pharmacother.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-04-27     Completed Date:  2001-08-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8213295     Medline TA:  Biomed Pharmacother     Country:  France    
Other Details:
Languages:  eng     Pagination:  170-3     Citation Subset:  IM    
Department of Animal Biology and CNR Center for Histochemistry, University of Pavia, Italy.
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MeSH Terms
Apoptosis / physiology*
DNA Fragmentation
Hyperthermia, Induced*
In Situ Nick-End Labeling
Microscopy, Electron
Multiple Myeloma / pathology,  therapy*,  ultrastructure

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