| Hypertensive retinal vascular changes: relationship to left ventricular hypertrophy and arteriolar changes before and after treatment. | |
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MedLine Citation:
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PMID: 1345141 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Eye-ground-photos were taken in twenty-eight previously untreated men with mild to moderate essential hypertension. The same eye was evaluated before and after 26 weeks of double-blind treatment with Enalapril or Hydrochlorothiazide. The vascular changes were assessed by using a more elaborate and refined grading than the Keith-Wagener-Barker scale. All photos were examined by the same observer without knowledge of blood pressure, type of treatment or the order in which the photos had been taken. There were significant positive correlations between the vascular alterations in the retina in the untreated state and left ventricular wall thickness (echocardiography), minimal vascular resistance in the calf (plethysmography) and blood pressure respectively. Treatment with Enalapril decreased the reflection of the retinal arterial wall significantly and reduced the narrowing of arteries and arterio-venous crossing phenomena non-significantly. Hydrochlorothiazide did not affect any of the retinal vascular changes. It can be concluded that this relatively simple technique of evaluating eye-ground-photos with a new grading scale, when used in non-malignant hypertension, gives a useful assessment of the degree of hypertensive target organ damage in the retina as well as in other important target organs, i.e. the heart and vascular beds. In addition, Enalapril positively affects hypertensive retinopathy in contrast to Hydrochlorothiazide, reflecting what happens to structural cardiovascular changes in the rest of the body. |
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Authors:
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B Dahlöf; S Stenkula; L Hansson |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Blood pressure Volume: 1 ISSN: 0803-7051 ISO Abbreviation: Blood Press. Publication Date: 1992 May |
Date Detail:
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Created Date: 1994-06-27 Completed Date: 1994-06-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9301454 Medline TA: Blood Press Country: NORWAY |
Other Details:
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Languages: eng Pagination: 35-44 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Göteborg, Ostra Hospital, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antihypertensive Agents / therapeutic use* Arterioles / pathology Child Double-Blind Method Echocardiography Enalapril / therapeutic use Humans Hydrochlorothiazide / therapeutic use Hypertension / complications*, drug therapy, pathology* Hypertrophy, Left Ventricular / etiology*, ultrasonography Male Middle Aged Photography Prospective Studies Retinal Vessels / drug effects, pathology* |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 58-93-5/Hydrochlorothiazide; 75847-73-3/Enalapril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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