Document Detail

Hypertensive left ventricular hypertrophy is linked to an enhanced catecholamine response to submaximal exercise.
MedLine Citation:
PMID:  10411665     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The serial plasma catecholamine response to exercise has not been studied fully in relation to left ventricular hypertrophy (LVH) in patients with hypertension (HT). This study determined whether plasma catecholamine responses to exercise are altered in essential HT in the presence or absence of LVH. MATERIALS AND METHODS: Plasma noradrenaline (NA) and plasma adrenaline (A) were measured at rest, during and after treadmill exercise in 59 hypertensive subjects and 22 age-matched control subjects. Patients were divided into LVH(-) (n = 20) and LVH(+) (n = 39) stratified by left ventricular mass index [LVMI: control subjects, LVH(-), LVH(+): 114 +/- 4, 105 +/- 3, 151 +/- 3 g m-2]. RESULTS: Exercise time (9.9 +/- 0.6, 7.6 +/- 0.7, 7.3 +/- 0.6 min) was shorter in patients with HT. Both systolic and diastolic blood pressures were higher in patients with HT, and no difference was observed between LVH(-) and LVH(+) patients. Resting plasma NA was not different (157 +/- 16, 173 +/- 17, 167 +/- 14 pg mL-1), but plasma NA at stage I (300 +/- 30, 342 +/- 40, 469 +/- 40 pg mL-1) was higher in LVH(+) patients than in LVH(-) patients or control subjects. Plasma A response to exercise was similar among the three groups. There was a positive correlation (r = 0.38, P < 0.001) between LVMI and Deltaplasma NA at stage I in all subjects. CONCLUSIONS: Patients with essential HT with LVH had augmented plasma NA response during submaximal exercise, whereas patients without LVH did not exhibit this augmentation. The positive correlation between LVMI and Deltaplasma NA suggested a possible association between the degree of cardiac hypertrophy and sympathetic activation during exercise.
T Kinugawa; M Mori; K Ogino; A Endo; M Kato; T Kato; S Osaki; A Ohtahara; O Igawa; I Hisatome; C Shigemasa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of clinical investigation     Volume:  29     ISSN:  0014-2972     ISO Abbreviation:  Eur. J. Clin. Invest.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-08-16     Completed Date:  1999-08-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0245331     Medline TA:  Eur J Clin Invest     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  594-602     Citation Subset:  IM    
The 1st Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan.
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MeSH Terms
Epinephrine / blood*
Exercise Test*
Hypertension / blood,  complications,  physiopathology*
Hypertrophy, Left Ventricular / blood,  complications,  physiopathology*
Middle Aged
Norepinephrine / blood*
Physical Exertion / physiology*
Reference Values
Regression Analysis
Ventricular Function, Left
Reg. No./Substance:
51-41-2/Norepinephrine; 51-43-4/Epinephrine

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