| Hypertensive disorders in pregnancy and subsequently measured cardiovascular risk factors. | |
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MedLine Citation:
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PMID: 20168095 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study the association of hypertensive pregnancy disorders with modifiable risk factors for cardiovascular and metabolic diseases and to estimate the feasibility for early detection and prevention. METHODS: This was a prospective study of 15,065 women with a first singleton birth between 1967 and 1995, who later participated in a population study that included standardized measurements of blood pressure, serum lipids, and body mass index (BMI). RESULTS: Women with a history of hypertensive disorders in pregnancy (preeclampsia or gestational hypertension) had higher BMI, higher blood pressure, and unfavorable levels of total cholesterol, low-density lipoprotein cholesterol, and triglycerides. Preeclampsia was associated with substantially higher risk of developing diabetes (odds ratio 3.8, 95% confidence interval [CI] 2.1-6.6), and if the hypertensive disorder occurred in more than one pregnancy, or in a relatively late pregnancy, the associations with later cardiovascular risk factors were substantially stronger. Thus, women with two episodes of preeclampsia were approximately 10 times more likely to use blood pressure medication at follow-up (adjusted odds ratio, 11.6, 95% CI 7.1-26.3), and in women with gestational hypertension in three consecutive pregnancies, systolic pressure was on average 27 mm Hg (95% CI 18-37 mm Hg) higher, and diastolic pressure was 12 mm Hg (95% CI 5-19 mm Hg) higher, compared with women without a history of hypertensive disorders. Adjustment for current body mass index partly attenuated these associations, suggesting that BMI may play an important mediating role. CONCLUSION: Women with a history of hypertensive disorders in pregnancy, and particularly women with recurrent pregnancy disorders, should be candidates for intervention intended to prevent premature cardiovascular disease. LEVEL OF EVIDENCE: II. |
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Authors:
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Elisabeth B Magnussen; Lars J Vatten; George Davey Smith; P?l R Romundstad |
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2172375 - Sodium pump numbers and cation transport of lymphocytes in pregnancy-induced hypertension. 19548865 - Use and safety of calcium channel blockers in obstetrics. 8199715 - Hypertension in pregnancy. 12563425 - Partial hellp syndrome: maternal and perinatal outcome. 6446425 - Suppression of mixed lymphocyte reactions by pregnancy serum. 12709915 - Hemostasis during normal pregnancy and puerperium. |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 114 ISSN: 1873-233X ISO Abbreviation: Obstet Gynecol Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2010-02-19 Completed Date: 2010-03-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 961-70 Citation Subset: AIM; IM |
Affiliation:
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Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure Body Mass Index Cardiovascular Diseases / epidemiology*, prevention & control Cholesterol, HDL / blood Cholesterol, LDL / blood Diabetes Mellitus / epidemiology Female Glucose Intolerance / epidemiology Humans Hyperlipidemias / epidemiology Hypertension, Pregnancy-Induced / epidemiology* Lipids / blood Middle Aged Norway / epidemiology Pre-Eclampsia / epidemiology Pregnancy Prospective Studies Recurrence Registries Risk Factors Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipids; 0/Triglycerides |
| Comments/Corrections | |
Comment In:
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Obstet Gynecol. 2009 Nov;114(5):958-60
[PMID:
20168094
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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