Document Detail

Hypertensive disorders in pregnancy and cognitive decline in the offspring up to old age.
MedLine Citation:
PMID:  23035059     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We tested whether maternal hypertensive disorders in pregnancy predict age-related change in cognitive ability in the offspring up to old age.
METHODS: Using mothers' blood pressure and urinary protein measurements from the maternity clinics and birth hospitals, we defined normotensive or hypertensive pregnancies in mothers of 398 men, who participated in the Helsinki Birth Cohort 1934-1944 Study. The men underwent the Finnish Defence Forces basic ability test twice: first during compulsory military service at age 20.1 (SD = 1.4) years and then in a retest at age 68.5 (SD = 2.9) years. The test yields a total score and subscores for tests measuring verbal, arithmetic, and visuospatial reasoning.
RESULTS: Men born after pregnancies complicated by a hypertensive disorder, compared with men born after normotensive pregnancies, scored 4.36 (95% confidence interval, 1.17-7.55) points lower on total cognitive ability at 68.5 years and displayed a greater decline in total cognitive ability (2.88; 95% confidence interval, 0.07-5.06) after 20.1 years. Of the subscores, associations were strongest for arithmetic reasoning.
CONCLUSION: Maternal hypertensive disorders in pregnancy predict lower cognitive ability and greater cognitive decline up to old age. A propensity to lower cognitive ability and decline up to old age may have prenatal origins.
Soile Tuovinen; Katri Räikkönen; Eero Kajantie; Markus Henriksson; Jukka T Leskinen; Anu-Katriina Pesonen; Kati Heinonen; Jari Lahti; Riikka Pyhälä; Hanna Alastalo; Marius Lahti; Clive Osmond; David J P Barker; Johan G Eriksson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-03
Journal Detail:
Title:  Neurology     Volume:  79     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-09     Completed Date:  2013-01-11     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1578-82     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure / physiology
Cognition / physiology*
Cognition Disorders / etiology*,  psychology
Follow-Up Studies
Hypertension, Pregnancy-Induced / physiopathology*,  psychology
Longitudinal Studies
Neuropsychological Tests
Prenatal Exposure Delayed Effects / psychology*
Grant Support
MC_UP_A620_1017//Medical Research Council; //British Heart Foundation
Comment In:
Evid Based Med. 2013 Dec;18(6):229-30   [PMID:  23412583 ]
Maturitas. 2013 Mar;74(3):206-7   [PMID:  23337615 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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