Document Detail


Hypertensive activity of synthesized PTH(25-34) and Ac-PTH(25-30)-NH2 in rats.
MedLine Citation:
PMID:  19013489     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Parathyroid hormone (PTH) is secreted by parathyroid glands and is the main known factor that control plasma calcium concentration. There are many indications that PTH or products of PTH degradation influence the mean arterial blood pressure (MAP). These observations might be important in diseases accompanied with the overproduction of PTH such as primary hyperparathyroidism (PHPT). It was shown that the six amino acids PTH precursor-PRO-PTH with reversed sequence (PRO-rs), which contains a rare tripeptide -Arg-Lys-Lys- fragment, induces significant hypertensive response in rats. This strong alkali tripeptide is also present in the position 25-27 of the PTH molecule. The aim of the present study was to synthesize, by the solid phase peptide synthesis method, PTH fragments including the -Arg-Lys-Lys- sequence and test their influence on blood pressure and calcium plasma concentration in rats. Our study demonstrated that PTH(25-34) and the acetylated amide analogue of PTH(25-30), (Ac-PTH(25-30)-NH(2)) were hypertensive in the physiological doses. The presence of strong alkali sequence -Arg-Lys-Lys- in PTH(25-30) fragment is not sufficient to induce hypertension either in physiological or pharmacological doses in rats. Therefore, both the proximity of the -Arg-Lys-Lys- sequence and length of the peptide might also play roles as pressure factors.
Authors:
Artur Lehmann; Konrad Boblewski; Arkadiusz Bonna; Zbigniew Maćkiewicz; Apolonia Rybczyńska
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-11-01
Journal Detail:
Title:  Peptides     Volume:  30     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-21     Completed Date:  2009-05-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  United States    
Other Details:
Languages:  eng     Pagination:  378-84     Citation Subset:  IM    
Affiliation:
Department of Pathophysiology, Faculty of Pharmacy, Medical University of Gdańsk, Tuwima 15, 80-210 Gdańsk, Poland. alehmann@amg.gda.pl
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects*
Calcium / blood
Dipeptides / chemistry,  metabolism
Male
Parathyroid Hormone / chemical synthesis,  chemistry,  pharmacology*
Peptide Fragments / chemical synthesis,  chemistry,  pharmacology*
Rats
Chemical
Reg. No./Substance:
0/Dipeptides; 0/Parathyroid Hormone; 0/Peptide Fragments; 0/acetyl-parathyroid hormone (25-30); 0/arginyllysine; 0/parathyroid hormone (25-34); 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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