Document Detail


Hypertension and white matter lesions are independently associated with apathetic behavior in healthy elderly subjects: the Sefuri brain MRI study.
MedLine Citation:
PMID:  19424282     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Apathy is defined as a syndrome of primary loss of motivation not attributable to emotional distress, intellectual impairment or consciousness disturbance. The aim of our study was to investigate the effects of vascular risk factors and silent ischemic brain lesions on apathetic behavior of community-dwelling elderly subjects. Brain MRI and other medical examinations were performed on 222 non-demented community-dwelling elderly subjects (96 men and 126 women, average age 70.1 years). The apathy group was defined as the most apathetic quintile determined by Starkstein's apathy scale. Silent infarction, deep white matter lesions (DWMLs) and periventricular hyperintensities were detected in 12.2, 39.2 and 22.5%, respectively. Linear regression analysis (Pearson) revealed that the scores on the apathy scale correlated slightly but significantly with logarithmically transformed scores of the Modified Stroop Test (r=0.135, P=0.045), but not with the Mini-Mental State Examination. The apathy group tended to have more high blood pressure (141.6/82.6 vs. 136.1/79.6 mm Hg), less prevalent hyperlipidemia (18 vs. 35%) and lower serum albumin. Multivariate analysis (the forward stepwise method of logistic analysis) revealed an independent correlation between the apathy and grade of DWMLs (odds ratio 1.826, 95% confidence interval (CI) 1.129-2.953 per grade) or diastolic blood pressure (DBP) (odds ratio 1.055, 95% CI 1.014-1.098 per mm Hg) after adjusting for possible confounders. The mean apathy scale score in the DBP>or=90 mm Hg group was significantly lower (more apathetic) than that in the DBP<80 group (P=0.011, analysis of covariance). This study showed that hypertension and DWMLs are independently associated with apathy in healthy elderly subjects.
Authors:
Hiroshi Yao; Yuki Takashima; Takahiro Mori; Akira Uchino; Manabu Hashimoto; Takefumi Yuzuriha; Yoshikazu Miwa; Toshiyuki Sasaguri
Publication Detail:
Type:  Journal Article     Date:  2009-05-08
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  32     ISSN:  1348-4214     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-06     Completed Date:  2009-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  586-90     Citation Subset:  IM    
Affiliation:
Center for Emotional and Behavioral Disorders, National Hospital Organization Hizen Psychiatric Center, Saga, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged / psychology*
Behavior / physiology*
Blood Pressure
Brain / pathology*
Brain Ischemia / pathology,  psychology
Cerebrovascular Disorders / pathology*,  psychology*
Cognition / physiology
Cognition Disorders / pathology,  psychology
Female
Humans
Hypertension / pathology*,  psychology*
Japan
Logistic Models
Magnetic Resonance Imaging
Male
Middle Aged
Neuropsychological Tests
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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