Document Detail

Hypertension and vascular dynamics in men and women with metabolic syndrome.
MedLine Citation:
PMID:  23287369     Owner:  NLM     Status:  In-Data-Review    
Metabolic syndrome (MetS), an important component of insulin resistance and cardiovascular (CV) risk, is defined by 3 or more of the following characteristics: abdominal obesity, hyperglycemia, hypertension, hypertriglyceridemia, and hypo-high-density lipoprotein cholesterolemia. Based on the previously published age- and sex-mediated DESIR (Data from an Epidemiological Study on the Insulin Resistance Syndrome) cohort and parallel central hemodynamic measurements, our goal was to evaluate the effects of MetS on brachial central pulse pressure (PP), PP amplification, aortic stiffness, and wave reflections. These data were then compared with those of patients with essential hypertension but without MetS for the same mean arterial pressure. Increased aortic stiffness, a major mechanical factor predicting CV risk, has been well identified as playing a role in MetS. Its age progression is proportional to the number of risk factors involved in MetS and is responsible for increased systolic blood pressure and decreased diastolic blood pressure with increasing age, the principal hallmarks of hypertension in the elderly. Beyond brachial pressure measurements, central hemodynamic parameters involve increased aortic stiffness, reduced wave reflections, and increased PP amplification, a parameter commonly associated with increased heart rate. With the exception of arterial stiffness, all these findings are opposite in direction to those observed in essential hypertension, in which MetS is absent. A divergent behavior of wave reflections and PP amplification, but not of arterial stiffness, is observed when hypertension is studied alone or when compared with MetS for the same mean arterial pressure. This pulsatile hemodynamic abnormality contributes independently to increase age- and sex-mediated CV risk, justifying new research regarding Framingham scores and drug treatment.
Michel E Safar; Beverley Balkau; Céline Lange; Athanase D Protogerou; Sébastien Czernichow; Jacques Blacher; Bernard I Levy; Harold Smulyan
Related Documents :
23453449 - Associations of serum uric acid levels with arterial wave reflections and central systo...
3757289 - Impaired sympathetic baroreflexes in prehypertensive dahl hypertension-sensitive rats.
25022429 - Global endocardial area change rate for the assessment of left ventricular relaxation a...
7777669 - Neural regulation of sympathetic nerve activity in heart failure.
24882549 - Dna methylation of human telomerase reverse transcriptase associated with leukocyte tel...
17673569 - Baroreflex control of muscle sympathetic nerve activity during skin surface cooling.
8160819 - Vascular ne responsiveness in portal hypertension: role of portal pressure and portosys...
22061789 - Biogenic amine production in spanish dry-cured "chorizo" sausage treated with high-pres...
14706539 - A nonpeptide provides insight into mechanisms that regulate drosophila melanogaster hea...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  61     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  12-9     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Paris Descartes University; AP-HP; Diagnosis and Therapeutic Center, Hôtel-Dieu, Paris, France. Electronic address:
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Synthesis and antioxidant activity of O-alkyl selenocarbamates, selenoureas and selenohydantoins.
Next Document:  Elevated plasma fibrinogen rather than residual platelet reactivity after clopidogrel pre-treatment ...