| Hypertension and vascular calcification: a vicious cycle? | |
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MedLine Citation:
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PMID: 22871891 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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It is now well established that hypertension is accompanied by remodeling of the arterial wall with significant modifications in extracellular matrix composition and in vascular cell phenotype. Some of these changes, particularly elastin fragments generation, increased proteases activity and activation of transforming growth factor-β signaling together with deposition of collagen and proteoglycans might generate a permissive soil for vascular calcification. On the other hand, calcium deposits within large arterial conduits can reduce vessel's elasticity and contribute to the generation of blood pressure pattern associated with vascular stiffness, namely isolated systolic hypertension. Hence, a hypothetical vicious cycle exists between hypertensive arterial damage and vascular calcification. Herein, we revised clinical and basic science findings supporting this possibility. |
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Authors:
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Marcello Rattazzi; Elisa Bertacco; Massimo Puato; Elisabetta Faggin; Paolo Pauletto |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-4 |
Journal Detail:
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Title: Journal of hypertension Volume: - ISSN: 1473-5598 ISO Abbreviation: J. Hypertens. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Medicine, University of Padova, Treviso, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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