Document Detail


Hypertension risk and caffeine's effect on cardiovascular activity during mental stress in young men.
MedLine Citation:
PMID:  1915209     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Examined the cardiovascular effects of caffeine plus behavioral stress in men low versus high in risk of essential hypertension. Caffeine (3.3 mg/kg, equivalent to 2 to 3 cups of coffee) or placebo was given on alternate days to 19 low-risk men (negative for parental hypertension and low-normal resting blood pressure, BP) and 20 high-risk men (positive history, high-normal BP). Forty minutes later, each worked for 15 min on a demanding psychomotor task during which BP, cardiac output, and vascular resistance were determined. During rest, caffeine raised vascular resistance in both groups. During the task, it supra-additively increased the systolic BP response by enhancing the rise in cardiac output, producing equivalent BP rises in both groups. Due to the higher resting pressures of the high-risk men, caffeine plus the task resulted in 50% of these having transient BP of 140/90 mg Hg or greater. Caffeine in combination with mental stress may produce undesirable BP in those at risk for hypertension.
Authors:
W R Lovallo; G A Pincomb; B H Sung; S A Everson; R B Passey; M F Wilson
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Health psychology : official journal of the Division of Health Psychology, American Psychological Association     Volume:  10     ISSN:  0278-6133     ISO Abbreviation:  Health Psychol     Publication Date:  1991  
Date Detail:
Created Date:  1991-11-14     Completed Date:  1991-11-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8211523     Medline TA:  Health Psychol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  236-43     Citation Subset:  IM    
Affiliation:
Veterans Affairs Medical Center, Oklahoma City, OK 73104.
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MeSH Terms
Descriptor/Qualifier:
Adult
Arousal / drug effects*
Blood Pressure / drug effects
Caffeine / administration & dosage,  adverse effects*
Double-Blind Method
Exercise Test / drug effects
Humans
Hypertension / chemically induced*,  genetics,  psychology*
Male
Risk Factors
Stress, Psychological / complications*
Grant Support
ID/Acronym/Agency:
HL32050/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
58-08-2/Caffeine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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