Document Detail

Hypertension and the renin-angiotensin system in the congenital hydronephrosis rat with non-obstructive pelviureteric junction abnormalities.
MedLine Citation:
PMID:  8788602     Owner:  NLM     Status:  MEDLINE    
We examined the involvement of the renin-angiotensin system in the maintenance of hypertension of the rat with congenital hydronephrosis having no urinary tract obstruction. The congenital hydronephrosis rat (HNR) had a significantly higher systolic blood pressure (181 +/- 9.5 mm Hg in the male bilateral hydronephrosis rat, BHN, at 13 weeks of age, n = 10) than control Wistar-Imamichi rats (126 +/- 5.8 mm Hg). The plasma renin activity and plasma angiotensin-II concentration of BHN were decreased to 20.1 and 24.6% of those of control rats, respectively. There was a negative correlation between plasma angiotensin-II concentration and blood pressure. In addition, the effect of captopril and indomethacin on the high blood pressure of BHNs was similar to that of human low-renin essential hypertension. These findings suggest that the renin-angiotensin system activity was markedly lowered and that the involvement of the system in the maintenance of hypertension in HNRs is small.
K Tauchi; H Kanehara
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental nephrology     Volume:  4     ISSN:  1018-7782     ISO Abbreviation:  Exp. Nephrol.     Publication Date:    1996 Jan-Feb
Date Detail:
Created Date:  1996-10-18     Completed Date:  1996-10-18     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9302239     Medline TA:  Exp Nephrol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  60-4     Citation Subset:  IM    
Physiology and Biochemistry Section, Imamichi Institute for Animal Reproduction, Ibaraki, Japan.
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MeSH Terms
Angiotensin II / blood
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Antihypertensive Agents / therapeutic use
Captopril / therapeutic use
Cyclooxygenase Inhibitors / therapeutic use
Hydronephrosis / complications,  congenital*,  physiopathology
Hypertension, Renal / drug therapy,  etiology*
Indomethacin / therapeutic use
Rats, Wistar
Renin / blood
Renin-Angiotensin System / physiology*
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Cyclooxygenase Inhibitors; 11128-99-7/Angiotensin II; 53-86-1/Indomethacin; 62571-86-2/Captopril; EC

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