Document Detail


Hypertension-related coronary thrombosis: prothrombic role of angiotensin II.
MedLine Citation:
PMID:  7966432     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although hypertension is a major risk factor in acute myocardial infarction, concomitant hypercoagulability causing thrombosis leading to myocardial infarction remains unproven for lack of an appropriate coagulation test. This study was devised to determine whether a modified recalcification time (MRT) test can demonstrate that angiotensin II, a potent vasoconstrictor, also accelerates coagulation to promote thrombosis. The MRT incorporates blood cells and chemical coagulants for maximizing sensitivity. Four groups (A, B, C, and D) of aliquots of citrated human blood were incubated for 2 hours at 37 degrees C after adding to A--20 microL saline, to B--10 micrograms Escherichia coli endotoxin, to C--20 micrograms angiotensin II, and to D--a combination of E coli endotoxin and angiotensin II. The experiment was repeated with nonincubated aliquots. Modified recalcification time values +/- standard deviation in minutes were: A--5.5 +/- 1.5, B--4.6 +/- 1.1, C--4.9 +/- 1.0, and D--3.9 +/- 1.0. Significance (Student's t test) was as follows: B versus A P < .001; C versus A, P < .05; C versus D, P < .001; B versus C, P < .05; and B versus D, P < .001. No significant changes occurred in nonincubated blood. We conclude that angiotensin II has a hypercoagulable effect, as does endotoxin. The hypercoagulability in concert with vasospasm can explain the role of hypertension in acute myocardial infarction. This in vitro study excludes the role of other in vivo mechanisms in the development of angiotensin II-induced hypercoagulability.
Authors:
C R Spillert; S Sun; M A Miller; E J Lazaro
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the National Medical Association     Volume:  86     ISSN:  0027-9684     ISO Abbreviation:  J Natl Med Assoc     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1994-12-22     Completed Date:  1994-12-22     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503090     Medline TA:  J Natl Med Assoc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  686-8     Citation Subset:  IM    
Affiliation:
Department of Surgery, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark 07103-2757.
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MeSH Terms
Descriptor/Qualifier:
Angiotensin II / physiology*
Blood Coagulation*
Blood Coagulation Tests / methods
Coronary Thrombosis / etiology,  physiopathology*
Humans
Hypertension / complications*
Risk Factors
Chemical
Reg. No./Substance:
11128-99-7/Angiotensin II
Comments/Corrections

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