| Hypertension-related coronary thrombosis: prothrombic role of angiotensin II. | |
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MedLine Citation:
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PMID: 7966432 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although hypertension is a major risk factor in acute myocardial infarction, concomitant hypercoagulability causing thrombosis leading to myocardial infarction remains unproven for lack of an appropriate coagulation test. This study was devised to determine whether a modified recalcification time (MRT) test can demonstrate that angiotensin II, a potent vasoconstrictor, also accelerates coagulation to promote thrombosis. The MRT incorporates blood cells and chemical coagulants for maximizing sensitivity. Four groups (A, B, C, and D) of aliquots of citrated human blood were incubated for 2 hours at 37 degrees C after adding to A--20 microL saline, to B--10 micrograms Escherichia coli endotoxin, to C--20 micrograms angiotensin II, and to D--a combination of E coli endotoxin and angiotensin II. The experiment was repeated with nonincubated aliquots. Modified recalcification time values +/- standard deviation in minutes were: A--5.5 +/- 1.5, B--4.6 +/- 1.1, C--4.9 +/- 1.0, and D--3.9 +/- 1.0. Significance (Student's t test) was as follows: B versus A P < .001; C versus A, P < .05; C versus D, P < .001; B versus C, P < .05; and B versus D, P < .001. No significant changes occurred in nonincubated blood. We conclude that angiotensin II has a hypercoagulable effect, as does endotoxin. The hypercoagulability in concert with vasospasm can explain the role of hypertension in acute myocardial infarction. This in vitro study excludes the role of other in vivo mechanisms in the development of angiotensin II-induced hypercoagulability. |
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Authors:
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C R Spillert; S Sun; M A Miller; E J Lazaro |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the National Medical Association Volume: 86 ISSN: 0027-9684 ISO Abbreviation: J Natl Med Assoc Publication Date: 1994 Sep |
Date Detail:
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Created Date: 1994-12-22 Completed Date: 1994-12-22 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7503090 Medline TA: J Natl Med Assoc Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 686-8 Citation Subset: IM |
Affiliation:
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Department of Surgery, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark 07103-2757. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II
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physiology* Blood Coagulation* Blood Coagulation Tests / methods Coronary Thrombosis / etiology, physiopathology* Humans Hypertension / complications* Risk Factors |
| Chemical | |
Reg. No./Substance:
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11128-99-7/Angiotensin II |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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