| Hypertension and progression of renal disease. | |
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MedLine Citation:
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PMID: 10928300 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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That systemic hypertension is involved in the progression of human renal disease is mostly suggested by the way anti-hypertensive treatment affects the course of the disease. Clinical evidence has been obtained from observational studies as well as from studies of dietary protein restriction. In addition, several trials have compared the effects of different antihypertensive agents. The angiotensin-converting-enzyme inhibitors have the best renoprotective effect when compared to conventional agents and calcium channel blockers. In most studies, ACE-inhibitors approximately halved the risk of progressive renal functional deterioration in patients with non-diabetic nephropathies; this protection was associated with a significant reduction in systemic blood pressure and proteinuria. Statistical analysis, however, also suggests a direct effect of ACE-inhibitors on the kidney. |
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Authors:
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G Maschio; L Oldrizzi; C Marcantoni; C Rugiu |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of nephrology Volume: 13 ISSN: 1121-8428 ISO Abbreviation: J. Nephrol. Publication Date: 2000 May-Jun |
Date Detail:
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Created Date: 2000-11-20 Completed Date: 2000-11-30 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9012268 Medline TA: J Nephrol Country: ITALY |
Other Details:
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Languages: eng Pagination: 225-7 Citation Subset: IM |
Affiliation:
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Division of Nephrology, University Hospital, Verona, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin-Converting Enzyme Inhibitors
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therapeutic use Antihypertensive Agents / therapeutic use Disease Progression Humans Hypertension / complications*, drug therapy Kidney Diseases / complications*, physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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