Document Detail


Hypertension produced by a high sodium diet in the borderline hypertensive rat (BHR).
MedLine Citation:
PMID:  3436073     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of high dietary sodium (8%) on blood pressure in spontaneously hypertensive (SHR), borderline hypertensive (BHR), and normotensive Wistar-Kyoto (WKY) rats was determined weekly by tail cuff plethysmography for one week of baseline and four weeks of diet. After 4 weeks, significant elevations in systolic blood pressure were found in SHR and BHR groups, but not in WKY. BHR studied an additional 4 weeks showed a further progression of hypertension, reaching levels nearly equal to control SHR. Direct measurement of arterial pressure in conscious animals in their home cage confirmed the elevation in pressure in both SHR and BHR groups. Metabolic studies revealed that the high sodium diet reduced body weight in SHR and BHR strains, but not in WKY. Although both urinary volumes and sodium excretion values were significantly lower in SHR and BHR compared with WKY, this effect disappeared when adjustments for body weight were made. Plasma norepinephrine determinations revealed a significant response to cold stress in all groups. Plasma epinephrine was elevated in all strains in response to cold stress; however, a consistent statistical elevation was seen only in WKY. The BHR is discussed as a model for determining the triggers responsible for environmentally-induced hypertension.
Authors:
J E Lawler; B J Sanders; Y F Chen; S Nagahama; S Oparil
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical and experimental hypertension. Part A, Theory and practice     Volume:  9     ISSN:  0730-0077     ISO Abbreviation:  Clin Exp Hypertens A     Publication Date:  1987  
Date Detail:
Created Date:  1988-04-06     Completed Date:  1988-04-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8207790     Medline TA:  Clin Exp Hypertens A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1713-31     Citation Subset:  IM    
Affiliation:
Physiology Program, University of Tennessee, Knoxville 37996.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure
Epinephrine / blood
Hypertension / etiology*,  physiopathology
Male
Norepinephrine / blood
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Sodium, Dietary / administration & dosage,  adverse effects*
Species Specificity
Stress, Physiological / physiopathology
Grant Support
ID/Acronym/Agency:
HL-19680/HL/NHLBI NIH HHS; HL-22544/HL/NHLBI NIH HHS; HL-25451/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Sodium, Dietary; 51-41-2/Norepinephrine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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