| Hypertension and primary hyperparathyroidism: the role of adrenergic and renin-angiotensin-aldosterone systems. | |
| | |
MedLine Citation:
|
PMID: 7565468 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Primary hyperparathyroidism (HPTH) is frequently associated with hypertension. To date, the relationship between these two conditions is still not clear. We have studied 34 consecutive patients with primary HPTH due to a parathyroid adenoma. The diagnosis was later surgically confirmed in 32 cases. Ten of thirty-four HPTH patients were hypertensive. Before adenomectomy (PTHX) and 1-2 months after PTHX, we measured the following parameters in all patients: circulating levels of total and ionized Ca, intact immunoreactive parathormone (iPTH) (1-84), plasma renin activity (PRA), aldosterone, and daily total urinary catecholamine excretion. Moreover, 10 hypertensive HPTH patients, 10 normotensive HPTH patients, compared to 10 to 10 sex- and age-matched healthy normotensive subjects, underwent an acute norepinephrine test to assess vascular reactivity to a pressor agent. Before PTHX, no significant difference was observed between normotensive and hypertensive patients in all the above-mentioned variables, except for PRA and plasma aldosterone levels which were higher in hypertensive patients. Furthermore, the pressor response to the norepinephrine test was significantly greater in hypertensive HPTH patients than in the other 2 groups. After PTXH, serum Ca and intact iPHT (1-84) levels were reduced to normal values in all patients, while blood pressure, PRA and plasma aldosterone levels became normal in 8 of 10 hypertensive patients. The pressor response to the norepinephrine test was similar in the 2 groups. These results are consistent with the hypothesis of a direct effect of PTH on renin secretion which could contribute to the pathogenesis of hypertension and to the vessels sensitization to pressor agents. |
| | |
Authors:
|
C Gennari; R Nami; S Gonnelli |
Related Documents
:
|
11325668 - Cause of residual hypertension after adrenalectomy in patients with primary aldosteronism. 7411808 - Hyperaldosteronism, hyperparathyroidism, medullary sponge kidneys, and hypertension. 2536448 - Understanding the mechanism of adrenocortical steroid hypertension. 147128 - Hypertension, hypokalemia, hyporeninemia and severe target organ damage. 9516178 - Catecholamine response during 12 days of high-altitude exposure (4, 300 m) in women. 1516988 - Blood pressure after three different forms of correction of anemia in hemodialysis. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Mineral and electrolyte metabolism Volume: 21 ISSN: 0378-0392 ISO Abbreviation: Miner Electrolyte Metab Publication Date: 1995 |
Date Detail:
|
Created Date: 1995-11-13 Completed Date: 1995-11-13 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 7802196 Medline TA: Miner Electrolyte Metab Country: SWITZERLAND |
Other Details:
|
Languages: eng Pagination: 77-81 Citation Subset: IM |
Affiliation:
|
Institute of Internal Medicine and Medical Pathology, University of Siena, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenoma
/
complications,
physiopathology* Aged Case-Control Studies Female Humans Hyperparathyroidism / etiology, physiopathology* Hypertension / complications, physiopathology* Male Middle Aged Parathyroid Neoplasms / complications, physiopathology* Reference Values Renin-Angiotensin System / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Relation between parathyroid hormone and cardiac function in long-term hemodialysis patients.
Next Document: Implication of parathyroid hormone for the development of hypertension in young spontaneously hypert...