Document Detail

Hypertension and myocardial ischemia.
MedLine Citation:
PMID:  19427499     Owner:  NLM     Status:  MEDLINE    
Detailed studies over the past 30 years have built up an impressive evidence base for the presence of myocardial ischemia in patients who have hypertension. This relationship ranges from the obvious association with obstructive coronary artery disease to mechanisms related to hemodynamic, microcirculatory, and neuroendocrine abnormalities. All of these factors serve to destabilize the critical balance between myocardial oxygen supply and demand. We have at our disposal a range of sophisticated investigations that allow us to demonstrate the presence and extent of the ischemia and therefore to target specific therapies to reduce the risk to these patients. Achieving target BP and managing all reversible components of the patient's cardiovascular risk status reduce to a minimum the clinical sequelae of myocardial ischemia in this vulnerable population..
Brian P Murphy; Tony Stanton; Francis G Dunn
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Medical clinics of North America     Volume:  93     ISSN:  1557-9859     ISO Abbreviation:  Med. Clin. North Am.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-11     Completed Date:  2009-06-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985236R     Medline TA:  Med Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  681-95     Citation Subset:  AIM; IM    
Cardiac Department, Stobhill Hospital, Glasgow, Scotland, UK.
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MeSH Terms
Antihypertensive Agents / therapeutic use
Coronary Artery Disease / etiology
Endothelium / physiopathology
Hypertension / complications*,  diagnosis,  drug therapy,  physiopathology
Myocardial Ischemia / diagnosis,  drug therapy,  etiology*,  physiopathology
Myocardium / pathology
Neurosecretory Systems
Oxidative Stress
Risk Factors
Reg. No./Substance:
0/Antihypertensive Agents

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