| 'Hypertension' and 'microalbuminuria': the bell tolls for thee. | |
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MedLine Citation:
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PMID: 16374419 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Since the terms 'hypertension' and 'microalbuminuria' were first defined, data from numerous studies have documented the continuous, rather than dichotomous, relation between blood pressure, albumin excretion, and cardiovascular disease. Lower blood pressures, down to at least 115/75 mmHg, and lower albumin excretions, below an estimated 2 mg/day, are associated with less cardiovascular risk. We hypothesize that the abundances of modern civilization superimposed on the Paleolithic genotype of humans, which has not substantially changed in the last 10 000 years, have considerably shifted the 'normal' values for blood pressure and various biochemical indices such as albuminuria still found in today's stone-aged cultures to the 'neo-normal' values observed today in the rest of the modern world. Defining a large portion of the population as 'normal' based upon these dichotomous 'neo-normal' standards is not supported by the data, and therefore seems unjustifiable. We propose that the medical community consider abandoning the terms 'hypertension' and 'microalbuminuria' in favor of 'blood pressure-associated' and 'albuminuria-associated' disease. |
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Authors:
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J P Forman; B M Brenner |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Kidney international Volume: 69 ISSN: 0085-2538 ISO Abbreviation: Kidney Int. Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2005-12-23 Completed Date: 2006-03-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: United States |
Other Details:
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Languages: eng Pagination: 22-8 Citation Subset: IM |
Affiliation:
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Harvard Medical School, Boston, Massachusetts, USA. jforman@partners.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Albuminuria
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complications* Blood Pressure Cardiovascular Diseases / etiology*, prevention & control Cholesterol, LDL / blood Humans Hypertension / complications* |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, LDL |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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