Document Detail

Hypertension and the kidneys--inter-relationship and therapeutic approach.
MedLine Citation:
PMID:  10652908     Owner:  NLM     Status:  MEDLINE    
Over the last decade, a great body of evidence has pointed towards the role of kidneys in the genesis and maintenance of a hypertensive state. There exists a relationship between a rise in the blood pressure and a proportionate increase in the urinary excretion of sodium and water called the pressure-natriuresis curve. Chronic renal diseases are the most common causes of secondary hypertension accounting for 2-5% of all cases of secondary hypertension. The prevalence rate of renovascular hypertension based upon referral patterns range from 0.2% to 10% of hypertensive population. The data provided by the International Registries on end-stage renal disease have suggested that essential hypertension is an important cause of progressive renal damage. The pathological lesion observed in malignant hypertension is fibrinoid necrosis of the small arteries and arterioles. Amongst the armamentarium of antihypertensive drugs calcium channel antagonists and the angiotensin converting enzyme inhibitors have a role in limiting glomerular hypertension. The best modality to prevent and treat renal dysfunction in the presence of hypertension is an adequate and effective control of high blood pressure.
B K Sharma; N Sharma; S Jain
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of the Indian Medical Association     Volume:  97     ISSN:  0019-5847     ISO Abbreviation:  J Indian Med Assoc     Publication Date:  1999 Mar 
Date Detail:
Created Date:  2000-02-17     Completed Date:  2000-02-17     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7505608     Medline TA:  J Indian Med Assoc     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  91-5; 105     Citation Subset:  IM    
Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Calcium Channel Blockers / therapeutic use
Hypertension / physiopathology
Hypertension, Renal / drug therapy,  metabolism*
Kidney / physiopathology
Kidney Failure / etiology
Sodium / metabolism,  urine
Water / metabolism
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Calcium Channel Blockers; 7440-23-5/Sodium; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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