Document Detail

Hypertension and incident dementia in community-dwelling elderly Yoruba Nigerians.
MedLine Citation:
PMID:  21303353     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To investigate the relationship between hypertension and dementia incidence in community-dwelling elderly Yoruba (aged 70 years and above) because of sparse information on dementia and its risk factors in developing countries.
MATERIALS AND METHODS: Community-based, prospective study of consenting elderly Yoruba using two-stage design. Blood pressure was measured during the baseline evaluation at 2001 and hypertension was defined as BP ≥ 140/90 mmHg. Diagnosis of dementia and normal cognition was by consensus using standard criteria. Non-demented subjects from the 2001 evaluation wave were re-evaluated during the 2004 and 2007 waves for dementia. Logistic regression was used to examine the association of baseline hypertension and incident dementia, after adjusting for age, gender, education, and histories of stroke and smoking. P-values <0.05 were considered significant.
RESULTS: During the 6-year follow-up, 120 individuals developed dementia, while 1633 remained non-demented. The frequency of hypertension in the demented group was significantly higher than in the non-demented (70.0% vs 60.2%, P = 0.034). Baseline hypertension was a significant risk factor for dementia (OR = 1.52; 95% CI 1.01-2.30). Higher systolic, diastolic or pulse pressure was associated with increased risk (P < 0.05). Participants with diastolic BP ≥ 90 mmHg were at a significantly greater risk than those with readings below 70 mmHg (OR = 1.65; 95% CI 1.01-2.69).
CONCLUSIONS: Hypertension was associated with increased risk of dementia in elderly Yoruba and its appropriate treatment may lower the risk.
A Ogunniyi; K A Lane; O Baiyewu; S Gao; O Gureje; F W Unverzagt; J R Murrell; V Smith-Gamble; K S Hall; H C Hendrie
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-02-08
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  124     ISSN:  1600-0404     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-10-24     Completed Date:  2012-02-03     Revised Date:  2014-09-09    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  396-402     Citation Subset:  IM    
Copyright Information:
© 2011 John Wiley & Sons A/S.
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MeSH Terms
Aged, 80 and over
Blood Pressure
Dementia / epidemiology*,  etiology
Developing Countries
Hypertension / complications,  epidemiology*
Nigeria / epidemiology
Risk Factors
Grant Support
R01 AG009956/AG/NIA NIH HHS; R01 AG009956-12/AG/NIA NIH HHS; R01 AG09956/AG/NIA NIH HHS

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