Document Detail


Hypertension in women: the role of progesterone and aldosterone.
MedLine Citation:
PMID:  20443718     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The age-related course of blood pressure and its gender-related difference, as well as the incidence of hypertension, have been the subject of multiple experimental, clinical and epidemiological studies over the past decades. The role of the sex hormones estradiol and testosterone within this gender dimorphism has been investigated without conclusive results. In this review, we provide background information on the gender difference in blood pressure, describe the impact of progesterone and aldosterone, and discuss the pathophysiology of aldosteronism as well as the potential role of drospirenone as a gender-specific agent for the prevention and treatment of hypertension and for cardiovascular protection.
Authors:
E Boschitsch; S Mayerhofer; D Magometschnigg
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Climacteric : the journal of the International Menopause Society     Volume:  13     ISSN:  1473-0804     ISO Abbreviation:  Climacteric     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-06-14     Completed Date:  2010-09-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9810959     Medline TA:  Climacteric     Country:  England    
Other Details:
Languages:  eng     Pagination:  307-13     Citation Subset:  IM    
Affiliation:
Klimax Menopause Clinic, Linke Wienzeile 56, Vienna, Austria.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aldosterone / adverse effects,  physiology*
Aldosterone Antagonists / therapeutic use
Androstenes / administration & dosage,  therapeutic use
Animals
Cardiovascular Diseases / etiology
Diet, Sodium-Restricted
Estradiol / administration & dosage
Estrogens / adverse effects,  pharmacology,  physiology
Female
Humans
Hypertension* / complications,  drug therapy,  prevention & control
Middle Aged
Natriuresis
Progesterone / physiology*
Progesterone Congeners / adverse effects,  pharmacology
Renin-Angiotensin System / drug effects,  physiology
Risk Factors
Sex Characteristics
Chemical
Reg. No./Substance:
0/Aldosterone Antagonists; 0/Androstenes; 0/Estrogens; 0/Progesterone Congeners; 50-28-2/Estradiol; 52-39-1/Aldosterone; 57-83-0/Progesterone; 67392-87-4/drospirenone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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