Document Detail

Hypertension in response to IL-6 during pregnancy: role of AT1-receptor activation.
MedLine Citation:
PMID:  23002372     Owner:  NLM     Status:  Publisher    
BACKGROUND: Increases in interleukin 6 (IL-6) and agonistic autoantibodies to the angiotensin II type 1 receptor (AT1-AA) are proposed to be important links between placental ischemia and hypertension in preeclampsia. METHODS: The purpose of this study was to determine whether IL-6 (5 ng/day), infused into normal pregnant (NP) rats, increased mean arterial pressure (MAP) and AT1-AA. MAP was analyzed in the presence and absence of an angiotensin type 1 receptor (AT1R) antagonist, losartan, L. RESULTS: MAP and AT1-AA increased from 102 ± 2 to 118 ± 4 mmHg and 0.7 ± 0.3 NP to 14.1 ± 1.4 chronotropic units with chronic IL-6 infusion. MAP responses to IL-6 were abolished in losartan pretreated rats (85 ± 4 in NP + L vs 85 ± 3 mmHg in IL-6 + L). CONCLUSION: These data indicate that IL-6 stimulates AT1-AA and that activation of the AT1R mediates IL-6 induced hypertension during pregnancy.
Babbette Lamarca; Joshua Speed; Lillian Fournier Ray; Kathy Cockrell; Gerd Wallukat; Ralf Dechend; Joey Granger
Publication Detail:
Journal Detail:
Title:  International journal of interferon, cytokine and mediator research : IJIM     Volume:  2011     ISSN:  1179-139X     ISO Abbreviation:  Int J Infereron Cytokine Mediator Res     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2012-9-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101526749     Medline TA:  Int J Infereron Cytokine Mediator Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  65-70     Citation Subset:  -    
Departments of Obstetrics and Gynecology/Physiology, Center for Excellence in Renal and Cardiovascular Research, University of Mississippi Medical Center, Jackson, MS, USA.
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