Document Detail


Hypertension in renal parenchymal disease: why is it so resistant to treatment?
MedLine Citation:
PMID:  16528245     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The association between hypertension and chronic renal disease is well known. The pathogenesis of hypertension in patients with chronic kidney disease (CKD) is complex and multifactorial, which may explain why it is resistant to treatment. The traditional paradigm is that hypertension in CKD is due either to an excess of intravascular volume (volume dependent) or to excessive activation of the renin-angiotensin system in relation to the state of sodium/volume balance (renin-dependent hypertension). This review focuses on the importance of less established mechanisms, such as increased activity of the sympathetic nervous system, increased endothelin production, decreased availability of endothelium-derived vasodilators and structural changes of the arteries, renal ischemia, and sleep apnea.
Authors:
V M Campese; N Mitra; D Sandee
Related Documents :
7889195 - Role of the renin-angiotensin system in hypertension in the elderly.
2222965 - Calciotropic hormones in human and experimental hypertension.
14508195 - Dual renin-angiotensin system blockade restores blood pressure-renin dependency in indi...
557305 - Plasma renin activity during controlled hemorrhage in the dog.
19011245 - Determination of renal vascular resistance in dogs with diabetes mellitus and hyperadre...
17456065 - Reversal e/a value at end-inspiration might be more sensitive and accurate for diagnosi...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Kidney international     Volume:  69     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-10     Completed Date:  2006-06-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  967-73     Citation Subset:  IM    
Affiliation:
Department of Medicine, Division of Nephrology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA. campese@usc.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Antihypertensive Agents / therapeutic use*
Arteries / pathology,  physiopathology
Chronic Disease
Circadian Rhythm / physiology
Drug Resistance / physiology
Endothelins / physiology
Endothelium, Vascular / physiopathology
Humans
Hypertension / drug therapy*,  etiology,  physiopathology*
Iatrogenic Disease
Kidney Diseases / complications*,  physiopathology*
Oxidative Stress / physiology
Renin-Angiotensin System / physiology
Sleep Apnea Syndromes / complications,  physiopathology
Sympathetic Nervous System / physiopathology
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Endothelins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Vascular tone control in humans: insights from studies in Bartter's/Gitelman's syndromes.
Next Document:  Escherichia coli lipopolysaccharide inhibits renin activity in human mesangial cells.