| Hypertension in hypothyroidism: arterial pressure and hormone relationships. | |
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MedLine Citation:
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PMID: 4085135 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate the regulation of arterial pressure and vasoactive hormones in hypothyroidism associated with hypertension, we measured intra-arterial pressure and hourly venous hormones (renin, angiotensin II, aldosterone, catecholamines and cortisol) for 24 hours in five hypertensive patients with primary hypothyroidism before commencing treatment, and again after three to six months of thyroxine replacement therapy. Arterial pressure fell significantly after thyroxine replacement in four patients. Thyroxine treatment was associated with a fall in plasma norepinephrine levels together with a decline in slopes of norepinephrine/arterial pressure regression lines which suggests that the sympathetic system may contribute to the hypertension in hypothyroidism. Variability of heart rate, blood pressure and plasma norepinephrine fell with thyroxine replacement consistent with impaired damping of swings in sympathetic activity in the untreated state. Reciprocal changes in arterial pressure and renin-angiotensin-aldosterone system activity suggested that this system was not the mediator of hypertension in hypothyroidism. |
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Authors:
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A M Richards; M G Nicholls; E A Espiner; H Ikram; J G Turner; B E Brownlie |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and experimental hypertension. Part A, Theory and practice Volume: 7 ISSN: 0730-0077 ISO Abbreviation: Clin Exp Hypertens A Publication Date: 1985 |
Date Detail:
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Created Date: 1986-03-14 Completed Date: 1986-03-14 Revised Date: 2008-02-12 |
Medline Journal Info:
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Nlm Unique ID: 8207790 Medline TA: Clin Exp Hypertens A Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1499-514 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aldosterone / blood Blood Pressure* Body Weight Epinephrine / blood* Female Heart Rate Humans Hypertension / blood, complications*, physiopathology Hypothyroidism / blood, complications*, physiopathology Male Middle Aged Norepinephrine / blood* Posture Thyroxine / blood* |
| Chemical | |
Reg. No./Substance:
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51-41-2/Norepinephrine; 51-43-4/Epinephrine; 52-39-1/Aldosterone; 7488-70-2/Thyroxine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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