Document Detail

Hypertension in the first month of life.
MedLine Citation:
PMID:  3794327     Owner:  NLM     Status:  MEDLINE    
We reviewed our 10-year experience with neonatal hypertension. Fifty-three cases were identified, which represented 0.7% of all neonatal tertiary care admissions. Causes were identified in 23 (43%) neonates. These included acute tubular necrosis (n = 7), renal vascular abnormalities (n = 8), renal structural abnormalities (n = 4), interstitial nephritis (n = 2), and coarctation of the aorta (n = 2). No cause was identified in 30 (57%) infants. If the two neonates with coarctation are excluded, infants who had normal urinalyses, blood urea nitrogen (BUN), serum creatinine and plasma renin activity (PRA), had non-malignant hypertension that tended to be short-lived and always resolved spontaneously. In contrast, a cause of hypertension was found in 68% of those having an abnormal urinalysis, BUN, serum creatinine or PRA. There were two hypertensive deaths in this group. While the hypertension was usually more prolonged, it still generally resolved spontaneously by 1 year of age or following corrective surgery. Our experience indicates that diagnostic studies can be postponed if the urinalysis, BUN, serum creatinine and PRA are normal and if coarctation of the aorta has been excluded. If these preliminary studies are abnormal, however, a renal cause is likely and further studies are indicated.
K F Buchi; R L Siegler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of hypertension     Volume:  4     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1987-01-30     Completed Date:  1987-01-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  525-8     Citation Subset:  IM    
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MeSH Terms
Aortic Coarctation / complications
Blood Urea Nitrogen
Creatinine / blood
Hypertension / etiology*
Hypertension, Renovascular / etiology
Infant, Newborn
Kidney Tubular Necrosis, Acute / complications
Renal Artery Obstruction / complications
Urine / analysis
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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