Document Detail

Hypertension in end-stage renal failure: role of sympathetic nervous system, sodium balance and renal pressor system.
MedLine Citation:
PMID:  6381895     Owner:  NLM     Status:  MEDLINE    
120 subjects, including 16 normal volunteers, 23 essential hypertensive and 81 uraemic patients (34 before the start of haemodialysis and 47 during maintenance haemodialysis) were studied in order to evaluate the interrelationship between mean arterial pressure (MAP) and total exchangeable sodium (NaE), plasma renin activity (PRA) and plasma catecholamines (PC). Significant positive correlations were noted between MAP and PRA and between MAP and PC in the total group of uraemic patients. In patients under conservative treatment MAP correlated significantly with NaE and PRA. Multiple regression analysis demonstrated that the combined effect of NaE and PRA accounted for 50 per cent of the levels of MAP. In patients undergoing chronic haemodialysis MAP lost any correlation with NaE. In these patients the presence of hypertension seemed to be related to the values of PRA and PC. PC increased after two hours of walking and hypertensive patients had higher increments than normotensive patients. These data might support an important role for the adrenergic system in the maintenance of hypertension in dialysis patients.
P Zucchelli; A Zuccala; A Sturani; E Degli Esposti; A Ligabue; A Santoro; A Gattiani; C Chiarini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Life support systems : the journal of the European Society for Artificial Organs     Volume:  1     ISSN:  0261-989X     ISO Abbreviation:  Life Support Syst     Publication Date:    1983 Apr-Jun
Date Detail:
Created Date:  1984-10-09     Completed Date:  1984-10-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8219681     Medline TA:  Life Support Syst     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  101-11     Citation Subset:  IM    
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MeSH Terms
Blood Pressure
Dopamine beta-Hydroxylase / blood
Epinephrine / blood
Hypertension / physiopathology
Hypertension, Renal / physiopathology*
Kidney / innervation*
Kidney Failure, Chronic / physiopathology*,  therapy
Middle Aged
Norepinephrine / blood
Pressoreceptors / physiopathology*
Renal Dialysis
Renin / blood
Sodium / blood*
Sympathetic Nervous System / physiopathology*
Uremia / physiopathology
Reg. No./Substance:
51-41-2/Norepinephrine; 51-43-4/Epinephrine; 7440-23-5/Sodium; EC beta-Hydroxylase; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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