Document Detail

Hypertension in a cohort of African children with renal tumours.
MedLine Citation:
PMID:  16421703     Owner:  NLM     Status:  MEDLINE    
Hypertension is a frequent problem in children with renal tumour, yet there are few reports from centres in the third world. A retrospective study of blood pressure in a cohort of 46 patients with renal tumours seen over a 3-year period was carried out. Fifty percent of patients presenting with Wilms' tumour were hypertensive. Serum concentrations of active renin correlated poorly with blood pressure. There was no correlation between serum concentrations of active renin and tumour mass or histology. Specific antihypertensive therapy was offered to 11 patients who had either neurological or cardiac complications of hypertension. All other patients with Wilms' tumour had their blood pressure controlled by neoadjuvant chemotherapy. Patients with mesoblastic nephroma were managed by primary surgery. Patients with asymptomatic hypertension may be monitored as hypertension will resolve with neoadjuvant chemotherapy. Those with compelling symptomatology will require additional hypertensive medication.
G P Hadley; M Mars
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2006-01-19
Journal Detail:
Title:  Pediatric surgery international     Volume:  22     ISSN:  0179-0358     ISO Abbreviation:  Pediatr. Surg. Int.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-15     Completed Date:  2006-07-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8609169     Medline TA:  Pediatr Surg Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  219-23     Citation Subset:  IM    
Department of Paediatric Surgery, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Congella, Private Bag 7, 4013 Durban, South Africa.
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MeSH Terms
Africa / epidemiology
Biopsy, Needle
Blood Pressure / physiology*
Child, Preschool
Hypertension / blood,  epidemiology*,  etiology
Infant, Newborn
Kidney Neoplasms / complications*,  diagnosis
Renin / blood
Retrospective Studies
Risk Factors
Survival Rate
Tomography, X-Ray Computed
Reg. No./Substance:

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