Document Detail

Hypertension in acromegaly: hereditary hypertensive factor produces hypertension by enhancing IGF-I production.
MedLine Citation:
PMID:  8822320     Owner:  NLM     Status:  MEDLINE    
Sixty-four patients with acromegaly were retrospectively analyzed to study the incidence and cause of hypertension in acromegaly. WHO criteria indicate that 37.5% patients with acromegaly have hypertension. The blood pressure was positively correlated with age, the insulin-like growth factor I (IGF-I) and serum sodium (Na) concentration. In addition, IGF-I and Na were significantly different in hypertensive and normotensive groups. Seventy-five percent of hypertensive patients had a family history of hypertension. IGF-I, Na and blood pressure were significantly higher in patients with a family history of hypertension than in those without it. In patients with a family history of hypertension, blood pressure was positively correlated with IGF-I and serum Na, but IGF-I was not correlated with serum Na. In patients without such a family history, blood pressure had a good correlation only with age, and IGF-I was not significantly correlated with blood pressure. In addition, the incidence of hypertension in this group was the same as or lower than that in the general population. The above results suggest that the genetic factor produces hypertension in acromegaly by two ways, by increasing Na and enhancing IGF-I production by GH.
H Ohtsuka; I Komiya; T Aizawa; T Yamada
Publication Detail:
Type:  Historical Article; Journal Article    
Journal Detail:
Title:  Endocrine journal     Volume:  42     ISSN:  0918-8959     ISO Abbreviation:  Endocr. J.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-11-14     Completed Date:  1996-11-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9313485     Medline TA:  Endocr J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  781-7     Citation Subset:  IM; Q    
Department of Internal Medicine, Kashiwa City Hospital, Japan.
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MeSH Terms
Acromegaly / blood,  diagnosis,  genetics*
Chi-Square Distribution
Growth Hormone / blood
History of Medicine
Hypertension / blood,  epidemiology,  genetics*
Insulin-Like Growth Factor I / biosynthesis*,  metabolism
Middle Aged
Retrospective Studies
Reg. No./Substance:
67763-96-6/Insulin-Like Growth Factor I; 9002-72-6/Growth Hormone

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