| Hypertension in Cushing's syndrome. | |
| | |
MedLine Citation:
|
PMID: 16980206 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cushing's syndrome can be exogenous, resulting from the administration of glucocorticoids or adrenocorticotrophic hormone (ACTH), or endogenous, secondary to increased secretion of cortisol or ACTH. Hypertension is one of the most distinguishing features of endogenous Cushing's syndrome, as it is present in about 80% of adult patients and in almost half of children and adolescents patients. Hypertension results from the interplay of several pathophysiological mechanisms regulating plasma volume, peripheral vascular resistance and cardiac output, all of which may be increased. The therapeutic goal is to find and remove the cause of excess glucocorticoids, which, in most cases of endogenous Cushing's syndrome, is achieved surgically. Treatment of Cushing's syndrome usually results in resolution or amelioration of hypertension. However, some patients may not achieve normotension or may require a prolonged period of time for the correction of hypercortisolism. Therefore, therapeutic strategies for Cushing's-specific hypertension (to normalise blood pressure and decrease the duration of hypertension) are necessary to decrease the morbidity and mortality associated with this disorder. The various pathogenetic mechanisms that have been proposed for the development of glucocorticoid-induced hypertension in Cushing's syndrome and its management are discussed. |
| | |
Authors:
|
Maria Alexandra Magiakou; Penelope Smyrnaki; George P Chrousos |
Related Documents
:
|
14709846 - A case of acth-producing pheochromocytoma associated with pregnancy. 6603966 - A follow-up of the "low dose suppressible" hypercortisolism. 15527696 - Glucocorticoid excess and hypertension. 8491916 - Leydig cell tumor of the testis in klinefelter syndrome: mr detection. 1666176 - Chickenpox-associated acute retinal necrosis syndrome. 6586106 - Ectropion and epiphora in mcardle's syndrome. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Best practice & research. Clinical endocrinology & metabolism Volume: 20 ISSN: 1521-690X ISO Abbreviation: Best Pract. Res. Clin. Endocrinol. Metab. Publication Date: 2006 Sep |
Date Detail:
|
Created Date: 2006-09-18 Completed Date: 2006-12-07 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101120682 Medline TA: Best Pract Res Clin Endocrinol Metab Country: England |
Other Details:
|
Languages: eng Pagination: 467-82 Citation Subset: IM |
Affiliation:
|
Unit of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, University of Athens Medical School, Agia Sophia Children's Hospital, 11527 Goudi, Athens, Greece. mmayakou@med.uoa.gr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
11-beta-Hydroxysteroid Dehydrogenases
/
physiology Angiotensin II / physiology Antihypertensive Agents / therapeutic use Atherosclerosis / complications Catecholamines / pharmacokinetics Cushing Syndrome / complications*, epidemiology, surgery Glucocorticoids / pharmacology Humans Hypertension / complications*, drug therapy, epidemiology, etiology Models, Biological Renin-Angiotensin System / drug effects, physiology Vasoconstrictor Agents / pharmacology Vasodilator Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Antihypertensive Agents; 0/Catecholamines; 0/Glucocorticoids; 0/Vasoconstrictor Agents; 0/Vasodilator Agents; 11128-99-7/Angiotensin II; EC 1.1.1.146/11-beta-Hydroxysteroid Dehydrogenases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Incidentally discovered masses in hypertensive patients.
Next Document: Laparoscopic adrenalectomy.