Document Detail

Hypertension in African Americans with Heart Failure: Progression from Hypertrophy to Dilatation; Perhaps Not.
MedLine Citation:
PMID:  25411129     Owner:  NLM     Status:  Publisher    
AIM: Concentric hypertrophy is thought to transition to left ventricular (LV) dilatation and systolic failure in the presence of long standing hypertension (HTN). Whether or not this transition routinely occurs in humans is unknown.
METHODS: We consecutively enrolled African American patients hospitalized for acute decompensated volume overload heart failure (HF) in this retrospective study. All patients had a history of HTN and absence of obstructive coronary disease. Patients were divided into those with normal left ventricular ejection fraction (LVEF) and reduced LVEF. LV dimensions were measured according to standard ASE recommendations. LV mass was calculated using the ASE formula with Devereux correction.
RESULTS: Patients with normal LVEF HF were significantly older, female and had a longer duration of HTN with higher systolic blood pressure on admission. LV wall thickness was similarly elevated in both groups. LV mass was elevated in both groups however was significantly greater in the reduced LVEF HF group compared to the normal LVEF HF group. Furthermore, gender was an independent predictor for LV wall thickness in normal LVEF HF group.
CONCLUSION: In African American patients with HF our study questions the paradigm that concentric hypertrophy transitions to LV dilatation and systolic failure in the presence of HTN. Genetics and gender likely play a role in an individual's response to long standing hypertension.
Pallavi Solanki; Ramzan M Zakir; Rajiv J Patel; Sri-Ram Pentakota; James Maher; Christine Gerula; Muhamed Saric; Edo Kaluski; Marc Klapholz
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-20
Journal Detail:
Title:  High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension     Volume:  -     ISSN:  1179-1985     ISO Abbreviation:  High Blood Press Cardiovasc Prev     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-20     Completed Date:  -     Revised Date:  2014-11-21    
Medline Journal Info:
Nlm Unique ID:  9421087     Medline TA:  High Blood Press Cardiovasc Prev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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