| Hypertension-hyponatremia syndrome in neonates: case report and review of literature. | |
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MedLine Citation:
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PMID: 10772196 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypertension hyponatremia syndrome occurred in a 32-week male neonate following septicemic shock on Day 9. The systolic blood pressure rose from 60 to 85 mmHg as the serum sodium dropped from 136 to 121 mmol/L associated with natriuresis, polyuria, and dehydration. Convulsions occurred at a systolic blood pressure of 102 mmHg. Investigations for hypertension revealed hyper-reninemia without cardio/renovascular or neuroendocrine abnormalities. Salt supplementation and antihypertensive therapy with captopril led to resolution of natriuresis and hyponatremia. Review of literature revealed associated renovascular pathology in all neonatal cases of the syndrome reported so far. Renal ischemia from possible renal microthrombi may have been the triggering event in our case. Decline in renin levels during follow-up favors this hypothesis. |
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Authors:
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A S Daftary; S K Patole; J Whitehall |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: American journal of perinatology Volume: 16 ISSN: 0735-1631 ISO Abbreviation: Am J Perinatol Publication Date: 1999 |
Date Detail:
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Created Date: 2000-05-16 Completed Date: 2000-05-16 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8405212 Medline TA: Am J Perinatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 385-9 Citation Subset: IM |
Affiliation:
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Department of Neonatology, Kirwan Hospital for Women, Townsville, Queensland, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Captopril
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administration & dosage Follow-Up Studies Humans Hypertension, Renal / diagnosis*, drug therapy Hyponatremia / diagnosis*, drug therapy Infant, Newborn Infant, Premature* Male Respiration, Artificial Respiratory Distress Syndrome, Newborn / diagnosis, therapy Shock, Septic / diagnosis* Sodium / administration & dosage Syndrome Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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62571-86-2/Captopril; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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