Document Detail

Hypertension-hyponatremia syndrome in neonates: case report and review of literature.
MedLine Citation:
PMID:  10772196     Owner:  NLM     Status:  MEDLINE    
Hypertension hyponatremia syndrome occurred in a 32-week male neonate following septicemic shock on Day 9. The systolic blood pressure rose from 60 to 85 mmHg as the serum sodium dropped from 136 to 121 mmol/L associated with natriuresis, polyuria, and dehydration. Convulsions occurred at a systolic blood pressure of 102 mmHg. Investigations for hypertension revealed hyper-reninemia without cardio/renovascular or neuroendocrine abnormalities. Salt supplementation and antihypertensive therapy with captopril led to resolution of natriuresis and hyponatremia. Review of literature revealed associated renovascular pathology in all neonatal cases of the syndrome reported so far. Renal ischemia from possible renal microthrombi may have been the triggering event in our case. Decline in renin levels during follow-up favors this hypothesis.
A S Daftary; S K Patole; J Whitehall
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  American journal of perinatology     Volume:  16     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  1999  
Date Detail:
Created Date:  2000-05-16     Completed Date:  2000-05-16     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  385-9     Citation Subset:  IM    
Department of Neonatology, Kirwan Hospital for Women, Townsville, Queensland, Australia.
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MeSH Terms
Captopril / administration & dosage
Follow-Up Studies
Hypertension, Renal / diagnosis*,  drug therapy
Hyponatremia / diagnosis*,  drug therapy
Infant, Newborn
Infant, Premature*
Respiration, Artificial
Respiratory Distress Syndrome, Newborn / diagnosis,  therapy
Shock, Septic / diagnosis*
Sodium / administration & dosage
Treatment Outcome
Reg. No./Substance:
62571-86-2/Captopril; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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