| Hypertension, hypokalemia, hyporeninemia and severe target organ damage. | |
| | |
MedLine Citation:
|
PMID: 147128 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A 51-year-old woman with a 20-year history of severe hypertension and target organ damage had nondiuretic hypokalemia, kaluresis, suppressed plasma renin activity and elevated urinary excretion of aldosterone. Renal arteriography demonstrated unilateral renal artery stenosis secondary to fibromuscular hyperplasia. Blood pressure responded only minimally to almost all antihypertensive agents. Spironolactone, 300 to 400 mg/d, produced distinct improvement in blood pressure, which was maintained for 13 months. |
| | |
Authors:
|
G E Wilkins |
Related Documents
:
|
3921768 - Specificity and structural relationships of steroids which affect phospholipase/prostag... 8421998 - Antifibrotic effects of spironolactone in preventing myocardial fibrosis in systemic ar... 2972348 - Atrial natriuretic factor in the pediatric intensive care unit. 7485478 - Determinants of cardiac fibrosis in experimental hypermineralocorticoid states. 2695548 - Sodium-sensitive essential hypertension: emerging insights into an old entity. 6176568 - A reproducible canine model of nonocclusive mesenteric ischemia. |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Canadian Medical Association journal Volume: 114 ISSN: 0008-4409 ISO Abbreviation: Can Med Assoc J Publication Date: 1976 Feb |
Date Detail:
|
Created Date: 1978-05-24 Completed Date: 1978-05-24 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 0414110 Medline TA: Can Med Assoc J Country: CANADA |
Other Details:
|
Languages: eng Pagination: 241-3 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aldosterone
/
urine Blood Pressure / drug effects Cardiomegaly / etiology* Female Humans Hyperaldosteronism / complications Hypertension / complications*, drug therapy Hypokalemia / complications* Middle Aged Potassium / urine Renal Artery Obstruction / etiology* Renin / blood* Retinal Hemorrhage / etiology* Spironolactone / therapeutic use |
| Chemical | |
Reg. No./Substance:
|
52-01-7/Spironolactone; 52-39-1/Aldosterone; 7440-09-7/Potassium; EC 3.4.23.15/Renin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Organismic states and their effect on recovery from neurosurgery: a new perspective with implication...
Next Document: Sézary's syndrome and generalized plane xanthoma.