| Hypertension during reduction of long-term steroid therapy in young subjects with asthma. | |
| | |
MedLine Citation:
|
PMID: 1560165 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Corticosteroids can induce hypertension, which reportedly remits as the drug is withdrawn. We studied nine patients with steroid-requiring asthma, aged 9 to 16 years, who had elevated blood pressures during corticosteroid treatment. Unlike in previous studies, all nine patients developed hypertension during corticosteroid reduction. Diastolic blood pressures were 50 to 84 mm Hg during maximum corticosteroid therapy (1 to 4 mg/kg/day); these values were in the normal range for seven of the nine patients and in the high normal range for the other two patients. Maximum diastolic pressures were 100 to 120 mm Hg, 1 to 8 weeks after corticosteroid reduction was started. Hypertension occurred at 0% to 70% of their maximum corticosteroid dose. Corticosteroid reduction was the only medication change. Renal causes of hypertension were excluded. Six patients had levels of renin and aldosterone measured before onset of treatment. All six patients had elevated levels of renin, and five patients had elevated levels of aldosterone. Blood pressure elevations were resistant to diuretic therapy but responded rapidly to angiotensin-converting enzyme inhibitors. Caretakers of subjects with asthma need to be aware that hypertension may occur both during maximum corticosteroid use and during corticosteroid reduction. |
| | |
Authors:
|
B P Sanders; R J Portman; R A Ramey; M Hill; R C Strunk |
Related Documents
:
|
12589175 - Aldo is back: recent advances and unresolved controversies in hyperaldosteronism. 18594485 - Endocrine arterial hypertension: therapeutic approach in clinical practice. 2155075 - Failure to visualize bilateral adrenal glands in a patient with primary aldosteronism. 16920805 - Aldosterone impairs baroreflex sensitivity in healthy adults. 3568565 - Applications of applied potential tomography (apt) in respiratory medicine. 15073275 - Effects of simulated obstructive sleep apnoea on the human carotid baroreceptor-vascula... |
Publication Detail:
|
Type: Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The Journal of allergy and clinical immunology Volume: 89 ISSN: 0091-6749 ISO Abbreviation: J. Allergy Clin. Immunol. Publication Date: 1992 Apr |
Date Detail:
|
Created Date: 1992-05-14 Completed Date: 1992-05-14 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 1275002 Medline TA: J Allergy Clin Immunol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 816-21 Citation Subset: AIM; IM |
Affiliation:
|
Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colo. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adrenal Cortex Hormones / adverse effects* Aldosterone / blood, urine Asthma / drug therapy* Child Female Follow-Up Studies Humans Hypertension / chemically induced* Male Renin / blood Substance Withdrawal Syndrome* |
| Grant Support | |
ID/Acronym/Agency:
|
K07-AI-00543/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Adrenal Cortex Hormones; 52-39-1/Aldosterone; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The effect of inhaled salmeterol on methacholine responsiveness in subjects with asthma up to 12 hou...
Next Document: Effect of dietary fish oil supplementation on the antigen-induced late-phase response in the skin.