| Hypertension despite dehydration during severe pediatric diabetic ketoacidosis. | |
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MedLine Citation:
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PMID: 21443581 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Deeter KH, Roberts JS, Bradford H, Richards T, Shaw D, Marro K, Chiu H, Pihoker C, Lynn A, Vavilala MS. Hypertension despite dehydration during severe pediatric diabetic ketoacidosis. Objective: Diabetic ketoacidosis (DKA) may result in both dehydration and cerebral edema but these processes may have opposing effects on blood pressure. We examined the relationship between dehydration and blood pressure in pediatric DKA. Design: A retrospective review was performed at Seattle Children's Hospital, Seattle, WA. Participants were hospitalized children less than 18 yr. Intervention(s) or main exposure was to patients with DKA (venous pH < 7.3, glucose > 300 mg/dL, HCO(3) < 15 mEq/L, and urinary ketosis). Dehydration was calculated as percent body weight lost at admission compared to discharge. Hypertension (systolic and/or diastolic blood pressure (DBP) percentile > 95%) was defined based on National Heart, Lung, and Blood Institute (NHLBI, 2004) nomograms and hypotension was defined as systolic blood pressure (SBP) <70 + 2 [age]. Results: Thirty-three patients (median 10.9 yr; range 10 months to 17 yr) were included. Fifty-eight percent of patients (19/33) had hypertension on admission before treatment and 82% had hypertension during the first 6 h of admission. None had admission hypotension. Hypertension 48 h after treatment and weeks after discharge was common (28 and 19%, respectively). Based on weight gained by discharge, 27% of patients had mild, 61% had moderate, and 12% presented with severe dehydration. Conclusion: Despite dehydration, most children admitted with severe DKA had hypertension. |
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Authors:
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Kristina H Deeter; Joan S Roberts; Heidi Bradford; Todd Richards; Dennis Shaw; Kenneth Marro; Harvey Chiu; Catherine Pihoker; Anne Lynn; Monica S Vavilala |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-28 |
Journal Detail:
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Title: Pediatric diabetes Volume: - ISSN: 1399-5448 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100939345 Medline TA: Pediatr Diabetes Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 John Wiley & Sons A/S. |
Affiliation:
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Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA, USA Department of Radiology, University of Washington, Seattle, WA, USA Department of Anesthesiology, University of Washington, Seattle, WA, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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