Document Detail

Hypertension and components of vascular resistance.
MedLine Citation:
PMID:  2032393     Owner:  NLM     Status:  MEDLINE    
1. In renal wrap hypertension in the rabbit and in essential hypertension in humans, non-autonomic components of resistance are the major factors contributing to elevated blood pressure. 2. The central nervous system plays an important role in moment to moment blood pressure control but is not responsible for maintenance of elevated pressure in essential hypertension. 3. Specific regions of the brain-stem maintain vascular tone through the effects of bulbospinal neurones which are organized both topographically and by chemical content. 4. Structural wall thickening in resistance vessels in hypertension is a manifestation of an abnormality of a growth controlling process. 5. Although several structural muscle growth factors have been identified, it is likely that only a few regulatory processes are critical. 6. Future studies in hypertension should examine associations between genetic markers of medial thickening and environmental influences.
M J West
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  18     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  1991 Jan 
Date Detail:
Created Date:  1991-06-26     Completed Date:  1991-06-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  61-4     Citation Subset:  IM    
Department of Medicine, University of Queensland, Brisbane, Australia.
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MeSH Terms
Blood Pressure
Blood Vessels / pathology
Brain Stem / physiopathology
Hypertension / genetics,  pathology,  physiopathology*
Vascular Resistance*

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