Document Detail

Hypertension and cognitive function. Blood pressure regulation and cognitive function: a review of the literature.
MedLine Citation:
PMID:  15700945     Owner:  NLM     Status:  MEDLINE    
High blood pressure raises the risks of vascular dementia and cognitive dysfunction in older adults, by acting on the cerebral vasculature and directly on the brain itself. Clinical trials and observational studies have shown that treating hypertension to target (<140/90 mm Hg) not only lessens morbidity and mortality, but also improves quality of life and preserves cognitive function. Yet, only 34% of hypertensive Americans currently have their hypertension under control, despite widespread treatment. Although single drug therapy is effective in treating hypertension, most patients will require combination drug treatment. Combination therapy--typically a diuretic with an ACE inhibitor, an ARB, or a beta blocker--is appropriate for treatment of older patients, is well tolerated, and can effectively preserve cognitive function.
Vasilios Papademetriou
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Geriatrics     Volume:  60     ISSN:  0016-867X     ISO Abbreviation:  Geriatrics     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-02-09     Completed Date:  2005-03-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2985102R     Medline TA:  Geriatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  20-2, 24     Citation Subset:  AIM; IM    
Georgetown University, Washington, DC, USA.
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MeSH Terms
Antihypertensive Agents / therapeutic use*
Clinical Trials as Topic
Cognition Disorders / etiology*,  prevention & control*
Drug Therapy, Combination
Hypertension / complications*,  drug therapy*
Reg. No./Substance:
0/Antihypertensive Agents

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