Document Detail


Hypertension and cognitive decline in rural elderly Chinese.
MedLine Citation:
PMID:  19507297     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To examine the association between hypertension and cognitive decline in older adults.
DESIGN: Prospective observational study.
SETTING: Four rural counties in China.
PARTICIPANTS: Two thousand rural Chinese aged 65 and older (median age 70, range 65-92) participated in a baseline evaluation. A follow-up evaluation of 1,737 subjects was conducted 2.5 years after baseline.
MEASUREMENTS: Cognitive function was assessed using the Community Screening Instrument for Dementia (CSID), Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Word List Learning and Recall Tests, Indiana University (IU) Story Recall Test, Animal Fluency Test, and IU Token Test. Hypertension was defined as the mean of two readings of systolic blood pressure (BP) of 140 mmHg or greater, diastolic BP of 90 mmHg or greater, or according to self-report. Cognitive decline was derived as the difference between baseline and follow-up scores. Analysis of covariance models were used to estimate the association between hypertension, BP, and cognitive decline, adjusting for other covariates.
RESULTS: Greater decline was found on the CERAD 10-Word List Learning (P<.001) and Recall (P=.01) scores for subjects with hypertension than for those without. In particular, significantly greater decline was seen in the group with hypertension that was not taking medication than in the group without hypertension. No significant difference on cognitive decline was found between subjects with hypertension who were taking medication and those without hypertension.
CONCLUSION: Untreated hypertension was associated with greater cognitive decline in this Chinese cohort. Better hypertension detection and treatment in elderly people, especially in developing countries, may offer protection against cognitive decline.
Authors:
Sujuan Gao; Yinlong Jin; Frederick W Unverzagt; Chaoke Liang; Kathleen S Hall; Feng Ma; Jill R Murrell; Yibin Cheng; Janetta Matesan; Jianchao Bian; Ping Li; Hugh C Hendrie
Related Documents :
2145407 - Treatment of the elderly hypertensive patient.
435747 - Divergent views of hospital staff on detecting and managing hypertension.
21097047 - Classification of elderly as fallers and non-fallers using centre of pressure velocity.
7379447 - Reduction of digoxin-induced inotropism during quinidine administration.
21347687 - Bipolar radiofrequency-induced thermofusion of intestinal anastomoses-feasibility of a ...
6875007 - Counseling psychology: the impact of authority and peer pressure as training variables.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of the American Geriatrics Society     Volume:  57     ISSN:  1532-5415     ISO Abbreviation:  J Am Geriatr Soc     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-08     Completed Date:  2009-06-19     Revised Date:  2011-06-16    
Medline Journal Info:
Nlm Unique ID:  7503062     Medline TA:  J Am Geriatr Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1051-7     Citation Subset:  IM    
Affiliation:
Department of Medicine, Indiana University School of Medicine, 410 West 10th Street, Suite 3000, Indianapolis, IN 46202-2872, USA. sgao@iupui.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Asian Continental Ancestry Group
China / epidemiology
Cognition Disorders / epidemiology*
Female
Follow-Up Studies
Humans
Hypertension / epidemiology*
Male
Risk Factors
Rural Population
Grant Support
ID/Acronym/Agency:
P30 AG10133/AG/NIA NIH HHS; R01 AG009956-12/AG/NIA NIH HHS; R01 AG009956-13/AG/NIA NIH HHS; R01 AG009956-14/AG/NIA NIH HHS; R01 AG009956-14S1/AG/NIA NIH HHS; R01 AG009956-15/AG/NIA NIH HHS; R01 AG009956-16/AG/NIA NIH HHS; R01 AG009956-17/AG/NIA NIH HHS; R01 AG019181/AG/NIA NIH HHS; R01 AG019181-01A2/AG/NIA NIH HHS; R01 AG019181-02/AG/NIA NIH HHS; R01 AG019181-03/AG/NIA NIH HHS; R01 AG019181-04/AG/NIA NIH HHS; R01 AG019181-05/AG/NIA NIH HHS; R01 AG09956/AG/NIA NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Heart disease risk factors in midlife predict subclinical coronary atherosclerosis more than 25 year...
Next Document:  Improving the process of pain care in nursing homes: a literature synthesis.