| Hypertension associated polymorphisms in WNK1/WNK4 are not associated with hydrochlorothiazide response. | |
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MedLine Citation:
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PMID: 21704025 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVES: Our purpose was to investigate whether with-no-K[Lys] kinase (WNK) 1 and WNK4 genetic polymorphisms are associated with both hypertension and diuretics response. DESIGN AND METHODS: Two WNK1 and one WNK4 polymorphisms were detected in two independent populations (n=1592 and 602) for association with hypertension, and in two clinical trials of hydrochlorothiazide treatment (n=542 and 274) for association with diuretics response. RESULTS: Two polymorphisms were found to be associated with hypertension risk with odds ratio of 1.55 for WNK1 rs1468326 (P<0.001) and 1.88 for WNK4 rs9916754 (P<0.001) in the first population, and 1.54 for WKN1 rs1468326, and 1.82 for WNK4 rs9916754 in the second population. However, two clinical trials found no relationship between these WNK polymorphisms and systolic/diastolic blood pressure responses to 4 or 8weeks treatment of hydrochlorothiazide. CONCLUSION: Our findings suggest that hypertension associated polymorphisms in WNK1 and WNK4 may not be predictors for antihypertensive response to diuretics. |
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Authors:
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Yunfeng Han; Xiaohan Fan; Kai Sun; Xiaojian Wang; Yibo Wang; Jingzhou Chen; Yisong Zhen; Weili Zhang; Rutai Hui |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-17 |
Journal Detail:
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Title: Clinical biochemistry Volume: - ISSN: 1873-2933 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0133660 Medline TA: Clin Biochem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Inc. |
Affiliation:
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Department of Geriatrics, The Military General Hospital of Beijing PLA, Beijing, China; Hypertension Division, Department of Cardiology, Cardiovascular Institute & FuWai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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