Document Detail


Hypertension associated polymorphisms in WNK1/WNK4 are not associated with hydrochlorothiazide response.
MedLine Citation:
PMID:  21704025     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: Our purpose was to investigate whether with-no-K[Lys] kinase (WNK) 1 and WNK4 genetic polymorphisms are associated with both hypertension and diuretics response. DESIGN AND METHODS: Two WNK1 and one WNK4 polymorphisms were detected in two independent populations (n=1592 and 602) for association with hypertension, and in two clinical trials of hydrochlorothiazide treatment (n=542 and 274) for association with diuretics response. RESULTS: Two polymorphisms were found to be associated with hypertension risk with odds ratio of 1.55 for WNK1 rs1468326 (P<0.001) and 1.88 for WNK4 rs9916754 (P<0.001) in the first population, and 1.54 for WKN1 rs1468326, and 1.82 for WNK4 rs9916754 in the second population. However, two clinical trials found no relationship between these WNK polymorphisms and systolic/diastolic blood pressure responses to 4 or 8weeks treatment of hydrochlorothiazide. CONCLUSION: Our findings suggest that hypertension associated polymorphisms in WNK1 and WNK4 may not be predictors for antihypertensive response to diuretics.
Authors:
Yunfeng Han; Xiaohan Fan; Kai Sun; Xiaojian Wang; Yibo Wang; Jingzhou Chen; Yisong Zhen; Weili Zhang; Rutai Hui
Related Documents :
3912335 - Antipyretic activity of nimesulide suppositories: double blind versus diclofenac and pl...
9010695 - Haemodynamic effects and pharmacokinetics of oral d- and l-nebivolol in hypertensive pa...
1350935 - Haemodynamic effects of roxatidine, an h2-receptor antagonist.
6089325 - Enalapril and atenolol in primary hypertension--a comparative study of blood pressure l...
24338565 - Cross-sectional study of indices of dynamic components of ambulatory blood pressure and...
21625095 - The evils of intradialytic sodium loading.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-17
Journal Detail:
Title:  Clinical biochemistry     Volume:  -     ISSN:  1873-2933     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Inc.
Affiliation:
Department of Geriatrics, The Military General Hospital of Beijing PLA, Beijing, China; Hypertension Division, Department of Cardiology, Cardiovascular Institute & FuWai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Metabolism, function and mass spectrometric analysis of bis(monoacylglycero)phosphate and cardiolipi...
Next Document:  Vascular endothelial function assessed by a noninvasive ultrasound method and serum asymmetric dimet...