Document Detail


Hypertension as an unusual feature in an outbreak of tetrodotoxin poisoning.
MedLine Citation:
PMID:  2005668     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report an outbreak of tetrodotoxin poisoning resulting from consumption of ovaries of an unidentified species of fish. Thirty victims manifested the typical neurologic symptoms of tetrodotoxin poisoning. Although hypotension is the classically described blood pressure reaction, eight individuals developed hypertension (average blood pressure 192/110 mm Hg); one died of acute pulmonary edema. Semi-quantitative tetrodotoxin bioassay of two uneaten ovaries revealed tetrodotoxin concentrations of 54 Mouse Units/gm and 287 Mouse Units/gm, respectively. To gain insight into the unusual phenomenon of hypertension observed in our outbreak, we interviewed the victims, performed a funduscopic exam for hypertensive retinopathy and checked their blood pressure periodically in the ensuing year. Mild hypertension evidenced by retinopathy and elevated blood pressure was found in all seven who manifested hypertension during the acute event and survived. We postulate that individuals with pre-existing hypertension responded to the relatively small doses of tetrodotoxin with a dramatic rise in blood pressure. This resulted in the fatal outcome for one individual with severe coronary artery disease. Hypertension should be recognized as a possible feature of tetrodotoxin poisoning, especially in predisposed individuals.
Authors:
J F Deng; R L Tominack; H M Chung; W J Tsai
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of toxicology. Clinical toxicology     Volume:  29     ISSN:  0731-3810     ISO Abbreviation:  J. Toxicol. Clin. Toxicol.     Publication Date:  1991  
Date Detail:
Created Date:  1991-04-19     Completed Date:  1991-04-19     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8213460     Medline TA:  J Toxicol Clin Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  71-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, Veterans General Hospital, Taipei, Taiwan, ROC.
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Blood Pressure
Coronary Artery Disease / complications
Disease Outbreaks*
Female
Fishes, Poisonous
Foodborne Diseases* / complications,  epidemiology
Humans
Hypertension / etiology*
Male
Middle Aged
Tetrodotoxin / poisoning*
Chemical
Reg. No./Substance:
4368-28-9/Tetrodotoxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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